Author: M Thier

0000000000856239

AUTHOR

M Thier

showing 1 related works from this author

Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons

1999

The cytokine interleukin-6 (IL-6) has multiple functions in the immune and hematopoietic systems. IL-6 is related to ciliary neurotrophic factor (CNTF), a trophic factor for motoneurons, sensory dorsal root ganglion (DRG) neurons, and other neuronal subpopulations. Both act via related receptor complexes, consisting of one ligand-specific α-receptor subunit (IL-6R and CNTFR, respectively) and two signal-transducing receptor components. Even though IL-6 is expressed by neurons and glia, the functions of IL-6 in the nervous system are poorly understood. Here, we report that exogenous human IL-6 promotes the survival of dissociated newborn rat DRG neurons in vitro if supplemented with soluble …

Nervous systemCytoplasmCiliary neurotrophic factorCellular and Molecular NeuroscienceDorsal root ganglionNeurotrophic factorsGanglia SpinalNerve Growth FactormedicineAnimalsHumansCiliary Neurotrophic FactorNeurons AfferentReceptorAutocrine signallingInterleukin 6Cells CulturedCell DeathDose-Response Relationship DrugbiologyInterleukin-6Receptors Interleukin-6RatsCell biologyAutocrine Communicationmedicine.anatomical_structureAnimals Newbornnervous systembiology.proteinNeuroscienceNeurotrophinJournal of Neuroscience Research

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