0000000000856313

AUTHOR

Kenneth W. Fishbein

0000-0002-6353-4603

showing 2 related works from this author

Age and muscle function are more closely associated with intracellular magnesium, as assessed by 31P magnetic resonance spectroscopy, than with serum…

2019

Total serum magnesium is a common clinical measurement for assessing magnesium status; however, magnesium in blood represents less than 1% of the body’s total magnesium content. We measured intramuscular ionized magnesium by phosphorus magnetic resonance spectroscopy (31P-MRS) and tested the hypothesis that this measure better correlates with skeletal muscle function and captures more closely the effect of aging than the traditional measure of total serum magnesium. Data were collected from 441 participants (age 24–98 years) in the Baltimore Longitudinal Study of Aging (BLSA), a study of normative aging that encompasses a broad age range. Results showed that intramuscular ionized magnesium …

0301 basic medicinemedicine.medical_specialtySettore MED/09 - Medicina InternaPhysiologychemistry.chemical_element030209 endocrinology & metabolismmagnesiumIonized magnesiumlcsh:Physiologysarcopenia03 medical and health sciences0302 clinical medicineNegatively associatedPhysiology (medical)Internal medicineMedicineskeletal muscle31P magnetic resonance spectroscopy31030109 nutrition & dieteticslcsh:QP1-981business.industryMagnesiumagingSkeletal muscleMuscle weaknessNuclear magnetic resonance spectroscopymedicine.diseaseP magnetic resonance spectroscopyEndocrinologymedicine.anatomical_structurechemistrySarcopeniamuscle strengthmedicine.symptombusinessIntracellular
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Overexpression of CYB5R3 and NQO1, two NAD+-producing enzymes, mimics aspects of caloric restriction

2018

© 2018 The Authors.

0301 basic medicineAgingCalorie restrictionInflammationmedicine.disease_cause03 medical and health sciencesDownregulation and upregulationmedicineCytochrome b5 reductaseCalorie restrictionchemistry.chemical_classification030102 biochemistry & molecular biologybiologyCYB5R3Cell BiologyCell biology030104 developmental biologyEnzymechemistrySirtuinbiology.proteinNQO1NAD+ kinasemedicine.symptomCarcinogenesisMetabolic homeostasis
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