0000000000856494

AUTHOR

T. Paus

showing 2 related works from this author

Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

2022

Published August 23, 2022 The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures (word reading, nonword reading, spelling, phoneme awareness, and nonword repetition) in samples of 13,633 to 33,959 part…

NeuroinformaticsAdultkieli ja kieletAdolescentIndividualityQH426 GeneticsPolymorphism Single NucleotidelukeminenLanguage in InteractionYoung AdultSDG 3 - Good Health and Well-beingRA0421readingRA0421 Public health. Hygiene. Preventive MedicineHumansSpeechstudyPolymorphismReading jPreschoolChildQH426perinnöllisyysGenome-wide Association Study ; Language ; Meta-analysis ; ReadingLanguageMCCNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]genome-wide association studylanguageMultidisciplinarymeta-analyysi1184 Genetics developmental biology physiologykielitaito[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesDASSingle Nucleotide/dk/atira/pure/sustainabledevelopmentgoals/quality_educationmeta-analysisReadingGenetic LociChild Preschoolgenome-wide association study; language; meta-analysis; reading; Adolescent; Adult; Child; Child Preschool; Genetic Loci; Humans; Language; Polymorphism Single Nucleotide; Young Adult; Genome-Wide Association Study; Individuality; Reading; Speechperimälukutaitogenome-wide associationSDG 4 - Quality EducationGenome-Wide Association StudyProceedings of the National Academy of Sciences
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Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

2021

AbstractThe use of spoken and written language is a capacity that is unique to humans. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30-80%, depending on the trait. The relevant genetic architecture is complex, heterogeneous, and multifactorial, and yet to be investigated with well-powered studies. Here, we present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures: word reading, nonword reading, spelling, phoneme awareness, and nonword repetition, with total sample sizes ranging from 13,633 to 33,959 participants aged 5-26 years (1…

Variation (linguistics)Reading (process)media_common.quotation_subjectTraitGenome-wide association studyWritten languageHeritabilityPsychologySpellingGenetic architectureCognitive psychologymedia_common
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