0000000000856682
AUTHOR
ÀNgel Moreno-torres
Strategies for annotation and curation of translational databases: the eTUMOUR project
Altres ajuts: LSHC/CT2004-503094 The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database-the eTDB-was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-gene…
Multiproject–multicenter evaluation of automatic brain tumor classification by magnetic resonance spectroscopy
[EN] Automatic brain tumor classification by MRS has been under development for more than a decade. Nonetheless, to our knowledge, there are no published evaluations of predictive models with unseen cases that are subsequently acquired in different centers. The multicenter eTUMOUR project (2004-2009), which builds upon previous expertise from the INTERPRET project (2000-2002) has allowed such an evaluation to take place. A total of 253 pairwise classifiers for glioblastoma, meningioma, metastasis, and low-grade glial diagnosis were inferred based on 211 SV short TE INTERPRET MR spectra obtained at 1.5 T (PRESS or STEAM, 20-32 ms) and automatically pre-processed. Afterwards, the classifiers …
Automated quality control protocol for MR spectra of brain tumors.
Item does not contain fulltext eTUMOUR (http://www.etumour.net/) is acquiring a large database of brain tumor (1)H MR spectra to develop automated pattern recognition methods and decision support system (DSS) for tumor diagnosis. Development of accurate pattern-recognition algorithms requires spectra undistorted by artifacts, low signal-to-noise, or broad lines. eTUMOUR currently uses panels of expert spectroscopists to subjectively grade spectra as being acceptable or unacceptable. Automated quality control (QC) would be more satisfactory for several reasons: 1) to provide a reproducible objective classification of spectrum quality; 2) for use within the future DSS to prevent misdiagnosis …