6533b837fe1ef96bd12a2a03

RESEARCH PRODUCT

Strategies for annotation and curation of translational databases: the eTUMOUR project

Rubén Ferrer-lunaMargarida Julià-sapéAnna BarcelóFrancesc EstanyolAna Paula CandiotaÀNgel Moreno-torresMariola MierM. Carmen Martínez-bisbalCarles ArúsXavier RafaelAlina GarcíaMiguel LurgiBernardo Celda

subject

Quality ControlComputer sciencePermissioncomputer.software_genreData typeGeneral Biochemistry Genetics and Molecular BiologySet (abstract data type)Translational Research BiomedicalUploadAnnotationUser-Computer InterfaceData visualizationSoftwareNeoplasmsData MiningHumansInternetInformation retrievalDatabaseData curationbusiness.industrySpectrum AnalysisReproducibility of ResultsOriginal ArticlesMagnetic Resonance ImagingDatabases as TopicMetric SystemDatabase Management SystemsGeneral Agricultural and Biological SciencesbusinesscomputerInformation Systems

description

Altres ajuts: LSHC/CT2004-503094 The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database-the eTDB-was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-generated meta-data and specialized quèries and global permissions for senior curators and on the other, to establish a set of metrics to quantify its contents. The indispensable dataset (ID), completeness and pairedness indices were set. The database contains 1317 cases created as a result of the eT project and 304 from a previous project, INTERPRET. The number of cases fulfilling the ID was 656. Completeness and pairedness were heterogeneous, depending on the data type involved.

yearjournalcountryeditionlanguage
2012-11-01
10.1093/database/bas035https://ddd.uab.cat/record/171638