0000000000861493

AUTHOR

Conen David

showing 2 related works from this author

Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AFRANDOMISED): an open-label randomised controlled trial.

2017

Summary Background Atrial fibrillation is a major risk factor for recurrent ischaemic stroke, but often remains undiagnosed in patients who have had an acute ischaemic stroke. Enhanced and prolonged Holter-electrocardiogram-monitoring might increase detection of atrial fibrillation. We therefore investigated whether enhanced and prolonged rhythm monitoring was better for detection of atrial fibrillation than standard care procedures in patients with acute ischaemic stroke. Methods Find-AF randomised is an open-label randomised study done at four centres in Germany. We recruited patients with acute ischaemic stroke (symptoms for 7 days or less) aged 60 years or older presenting with sinus rh…

medicine.medical_specialtyIntention-to-treat analysisbusiness.industryAtrial fibrillation030204 cardiovascular system & hematologymedicine.disease3. Good healthlaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawInternal medicineClinical endpointCardiologyMedicineSinus rhythmNeurology (clinical)cardiovascular diseasesRisk factorbusinessStroke030217 neurology & neurosurgeryAtrial flutterThe Lancet. Neurology
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Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Fai…

2019

Importance Short-term infusions of single vasodilators, usually given in a fixed dose, have not improved outcomes in patients with acute heart failure (AHF). Objective To evaluate the effect of a strategy that emphasized early intensive and sustained vasodilation using individualized up-titrated doses of established vasodilators in patients with AHF. Design, Setting, and Participants Randomized, open-label blinded-end-point trial enrolling 788 patients hospitalized for AHF with dyspnea, increased plasma concentrations of natriuretic peptides, systolic blood pressure of at least 100 mm Hg, and plan for treatment in a general ward in 10 tertiary and secondary hospitals in Switzerland, Bulgari…

Malemedicine.medical_specialtyVasodilator AgentsComorbidityPatient Readmission01 natural sciencesDrug Administration Schedulelaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawCause of DeathInternal medicineClinical endpointHumansMedicine030212 general & internal medicine0101 mathematicsAdverse effectAgedCause of deathAged 80 and overHeart Failurebusiness.industry010102 general mathematicsHazard ratioGeneral Medicinemedicine.diseaseHospitalizationBlood pressureHeart failureAcute DiseaseFemalebusinessSacubitril ValsartanJAMA
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