0000000000862413
AUTHOR
F. Lo Cascio
Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
Alzheimer’s disease (AD) is one of over 18 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable neurofibrillary tangles (NFTs) and oligomers. Recently, it has been shown that tau oligomers are highly toxic in vitro and efficient seeds for the propagation of pathology as compared to NFTs. While the toxicity of recombinant tau oligomers has been studied extensively, within the same aggregation state, tau exhibits conformational differences, termed tau oligomeric strains. Due to the dynamic nature of these stra…
Fully automatic saliency-based subjects extraction in digital images
In this paper we present a novel saliency-based technique for the automatic extraction of relevant subjects in digital images. We use enhanced saliency maps to determine the most relevant parts of the images and an image cropping technique on the map itself to extract one or more relevant subjects. The contribution of the paper is two-fold as we propose a technique to enhance the standard GBVS saliency map and a technique to extract the most salient parts of the image. The GBVS saliency map is enhanced by applying three filters particularly designed to optimize the performance for the task of relevant subjects extraction. The extraction of relevant subjects is demonstrated on a manually ann…