0000000000862802

AUTHOR

G Isgro

showing 3 related works from this author

Digital image analysis of liver collagen predicts clinical outcome of recurrent hepatitis C virus 1 year after liver transplantation.

2011

Clinical outcomes of recurrent hepatitis C virus after liver transplantation are difficult to predict. We evaluated collagen proportionate area (CPA), a quantitative histological index, at 1 year with respect to the first episode of clinical decompensation. Patients with biopsies at 1 year after liver transplantation were evaluated by Ishak stage/grade, and biopsy samples stained with Sirius red for digital image analysis were evaluated for CPA. Cox regression was used to evaluate variables associated with first appearance of clinical decompensation. Receiver operating characteristic (ROC) curves were also used. A total of 135 patients with median follow-up of 76 months were evaluated. At 1…

AdultMaleTime FactorsAdolescentBiopsyHepatic Veins/physiopathologyKaplan-Meier EstimateLiver Cirrhosis/metabolism/pathology/physiopathology/*surgery/virologyRisk AssessmentSensitivity and Specificity*Image Interpretation Computer-AssistedYoung AdultPredictive Value of TestsRecurrenceRisk FactorsLondonHumansLiver/blood supply/*metabolism/pathology/*surgery/virologyChildAgedProportional Hazards ModelsRetrospective Studiesliver transplantationLiver Transplantation/*adverse effectsMiddle AgedROC CurveCollagen/*metabolismFemaleHepatitis C/complications/metabolism/pathology/physiopathology/*surgeryEnd Stage Liver Disease/pathology/physiopathology/*surgery/virologyVenous Pressure
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The relationship between transient elastography and histological collagen proportionate area for assessing fibrosis in chronic viral hepatitis

2012

Collagen proportionate area (CPA) has a better correlation with hepatic venous pressure gradient (HVPG) than with Ishak stage. Liver stiffness measurement (LSM) is proposed as non invasive marker of portal hypertension/disease progression. Our aim was to compare LSM and CPA with Ishak staging in chronic viral hepatitis, and HVPG in HCV hepatitis after transplantation. One hundred and sixty-nine consecutive patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections pre/post liver transplantation (LT), had a liver biopsy combined with LSM (transient elastography), CPA (biopsies stained with Sirius Red and evaluated by digital image analysis and expressed as CPA) and H…

AdultLiver CirrhosisMalemedicine.medical_specialtyCirrhosisHepatitis C virusmedicine.medical_treatmentBiopsyLiver transplantationmedicine.disease_causeGastroenterologyYoung AdultHepatitis B ChronicInternal medicinemedicineImage Processing Computer-AssistedHumansheterocyclic compoundsAgedtransient elastography histological collagen proportionate area fibrosis chronic viral hepatitis.medicine.diagnostic_testbusiness.industryfibrosisGastroenterologyHepatologyHepatitis C ChronicMiddle Agedmedicine.diseasetransient elastographychronic viral hepatitisLiver TransplantationTransplantationhistological collagen proportionate areaLiver biopsyMultivariate Analysiscardiovascular systemDisease ProgressionElasticity Imaging TechniquesRegression AnalysisFemaleCollagenTransient elastographyViral hepatitisbusiness
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Histological subclassification of cirrhosis

2010

medicine.medical_specialtyCirrhosisHepatologybusiness.industrymedicine.medical_treatmentcirrhosisMEDLINEHepatitis CLiver transplantationmedicine.diseaseGastroenterologyText miningFibrosisInternal medicineMedicinebusiness
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