0000000000868704
AUTHOR
Vinod Kumar
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia
Idiopathic achalasia is characterized by a failure of the lower esophageal sphincter to relax due to a loss of neurons in the myenteric plexus(1,2). This ultimately leads to massive dilatation and an irreversibly impaired megaesophagus. We performed a genetic association study in 1,068 achalasia cases and 4,242 controls and fine-mapped a strong MHC association signal by imputing classical HLA haplotypes and amino acid polymorphisms. An eight-residue insertion at position 227-234 in the cytoplasmic tail of HLA-DQ beta 1 (encoded by HLA-DQB1*05:03 and HLA-DQB1*06:01) confers the strongest risk for achalasia (P = 1.73 x 10(-19)). In addition, two amino acid substitutions in the. extracellular …
Soil Science Challenges in a New Era: A Transdisciplinary Overview of Relevant Topics
Transdisciplinary approaches that provide holistic views are essential to properly understand soil processes and the importance of soil to society and will be crucial in the future to integrate distinct disciplines into soil studies. A myriad of challenges faces soil science at the beginning of the 2020s. The main aim of this overview is to assess past achievements and current challenges regarding soil threats such as ero-sion and soil contamination related to different United Nations sustainable development goals (SDGs) including (1) sustainable food production, (2) ensure healthy lives and reduce environmental risks (SDG3), (3) ensure water availability (SDG6), and (4) enhanced soil carbo…
A review of ecological risk assessment and associated health risks with heavy metals in sediment from India
Abstract Heavy metal (HM) pollution in sediment is a serious concern particularly in developing nations, warranting an extensive survey to understand the current situation and propose possible remedial measures. This paper compiles the data of HMs cadmium (Cd), iron (Fe), cobalt (Co), manganese (Mn), arsenic (As), lead (Pb), chromium (Cr), copper (Cu), zinc (Zn) and nickel (Ni) in aquatic sediment from India from 1979 to 2017. It was found that mean values of Cu, Co, Zn, Pb, As, and Cr in Indian sediment were high in comparison to the Australian Interim Sediment Quality Guidelines, World Surface Rock Average, and the Threshold Effect Level for freshwater ecosystems. Anthropogenic activities…
Evaluation of the coupled high-resolution atmospheric chemistry model system MECO(n) using in situ and MAX-DOAS NO2 measurements
We present high spatial resolution (up to 2.2×2.2 km2) simulations focussed over south-west Germany using the online coupled regional atmospheric chemistry model system MECO(n) (MESSy-fied ECHAM and COSMO models nested n times). Numerical simulation of nitrogen dioxide (NO2) surface volume mixing ratios (VMRs) are compared to in situ measurements from a network with 193 locations including background, traffic-adjacent and industrial stations to investigate the model's performance in simulating the spatial and temporal variability of short-lived chemical species. We show that the use of a high-resolution and up-to-date emission inventory is crucial for reproducing the spatial variability and…
Simulation of organics in the atmosphere: evaluation of EMACv2.54 with the Mainz Organic Mechanism (MOM) coupled to the ORACLE (v1.0) submodel
Abstract. An updated and expanded representation of organics in the chemistry general circulation model EMAC (ECHAM5/MESSy for Atmospheric Chemistry) has been evaluated. First, the comprehensive Mainz Organic Mechanism (MOM) in the submodel MECCA (Module Efficiently Calculating the Chemistry of the Atmosphere) was activated with explicit degradation of organic species up to five carbon atoms and a simplified mechanism for larger molecules. Second, the ORACLE submodel (version 1.0) considers now condensation on aerosols for all organics in the mechanism. Parameterizations for aerosol yields are used only for the lumped species that are not included in the explicit mechanism. The simultaneous…
Ecological and human health risks appraisal of metal(loid)s in agricultural soils: a review
Agriculture is one of the major human activities that changed the landforms, water resources and the biogeochemical cycles. Pollution of agricultural soilsby metal(loid)s is a serious and global hazard but worldwide studies related to metal(loid)s pollution in agricultural soils are very limited. To fulfil this gap, metal(loid)s content in agricultural soils from 2001 to 2019 all over the world was reviewed. Multivariate statistical techniques, contamination indices and human health risk assessment were determined for the metal(loid)s. Among the analysed metal(loid)s, the average contents of Zn, Cu, Pb, Cr, Cd, As and Ni exceeded the Canadian, and China soil guidelines limits. The results o…
Evaluation of the coupled high-resolution atmospheric chemistry model system MECO(n) using in situ and MAX-DOAS NO<sub>2</sub> measurements
Abstract. We present high spatial resolution (up to 2.2×2.2 km2) simulations focussed over south-west Germany using the online coupled regional atmospheric chemistry model system MECO(n) (MESSy-fied ECHAM and COSMO models nested n times). Numerical simulation of nitrogen dioxide (NO2) surface volume mixing ratios (VMRs) are compared to in situ measurements from a network with 193 locations including background, traffic-adjacent and industrial stations to investigate the model's performance in simulating the spatial and temporal variability of short-lived chemical species. We show that the use of a high-resolution and up-to-date emission inventory is crucial for reproducing the spatial varia…
Combination of contamination indices and ecological risk assessment index for evaluation of pollution level in sediments
Abstract Sediments act as the key storehouse of heavy metals (HMs) and play a vital function in the transport and potential discharge of HMs. Lower basins and agricultural areas are frequently inundated with various pollutants from different origins, which are categorized as constant, bioaccumulative, and unsafe pollutants. Moreover, the unrestricted development of urban and rural parts of developing countries has a great influence on water quality and ultimately on sediments. The human contributions to HM pollution and allied ecological and health risks are discussed in this chapter. Also in this chapter, details of the single pollution indices and multiple pollution indices are described.…
Pollution assessment of heavy metals in soils of India and ecological risk assessment: A state-of-the-art
Soil is substantive component of biosphere, which is exposed to plethora of pollutants including heavy metals. These are added by natural as well as anthropogenic activities. Upsurge in heavy metal content affects all organisms by biomagnification. So, it becomes vital to create a database of heavy metals concentration in soil. This is relevant in countries where unsustainable intensive agriculture, industrial and urban development is in progress. The present review of the scientific literature from 1991 to 2018 on heavy metals in soils in India shows that Zn and Pb exceeded their limits for Indian natural soil guidelines (Zn 22.1 and Pb 13.1 μg/g), Canada (Zn 200 μg/g), Swedish (80 μg/g) a…