Metabolism of chlorobenzene and hexachlorobenzene by the zebra fish, Brachydanio rerio.

It is now becoming evident that in many cases metabolites have a greater toxic potential than the parent xenobiotic exposed. For this reason, the knowledge of biotransformation pathways of xenobiotics plays a substantial role in environmental monitoring programs. The zebra fish (Brachydanio rerio, Hamilton-Buchanan) has received increased attention as a model species for freshwater fish in environmental surveillance programs to evaluate potential health and impacts of anthropogenic chemicals. The metabolism of phenol and various substituted phenols in zebra fish has recently been studied. The purpose of the present study was to examine the metabolism of chlorobenzene and hexachlorobenzene (…