0000000000872064
AUTHOR
Sandra Fernández Rodríguez
Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction
Rationale: Accumulating evidence suggests that chronic alcohol consumption is associated with excessive oxidative damage and neuroinflammatory processes and these events have been associated to early alcohol withdrawal. In the present research we wonder if brain oxidative stress and neuroinflammation remains altered during prolonged withdrawal situations and whether these alterations can be correlated with relapse behavior in alcohol consumption. The effects of alcohol reintroduction were also evaluated Methods: We have used a model based on the alcohol deprivation effect (ADE) within a cohort of wild-type male Wistar rats. Two subpopulations were identified according to the alcohol relapse…
Study of the neurobiology of ethanol-relapse behaviour and its prevention with N-acetylcysteine: preclinical studies in rats
El trastorno por consume de alcohol (TCA) es una patología cíclica caracterizada por el excesivo consumo de alcohol, que incluye varias fases de intoxicación y abstinencia. Ya que el TCA es una patología recidivante, conocer el mecanismo que subyace la recaída es crucial para el desarrollo de nuevos fármacos anti-recaída. Recientemente, la N-acetilcisteína (NAC), un fármaco con propiedades antioxidantes, anti-inflamatorias y glutamatérgicas, se ha propuesto como una potencial farmacoterapia para prevenir la recaída en el consumo de alcohol. Con el fin de estudiar potenciales tratamientos anti-recaída, nuestro laboratorio ha usado el modelo preclínico basado en el fenómeno de deprivación del…