0000000000873327

AUTHOR

Julia Heim

showing 3 related works from this author

Silica-coated Au@ZnO Janus particles and their stability in epithelial cells

2020

Multicomponent particles have emerged in recent years as new compartmentalized colloids with two sides of different chemistry or polarity that have opened up a wide field of unique applications in medicine, biochemistry, optics, physics and chemistry. A drawback of particles containing a ZnO hemisphere is their low stability in biological environment due to the amphoteric properties of Zn2+. Therefore we have synthesized monodisperse Au@ZnO Janus particles by seed-mediated nucleation and growth whose ZnO domain was coated selectively with a thin SiO2 layer as a protection from the surrounding environment that imparts stability in aqueous media while the Au domain remained untouched. The thi…

chemistry.chemical_classificationMaterials scienceBiocompatibilityBiomoleculeDispersityBiomedical EngineeringNucleationNanotechnologyJanus particlesGeneral ChemistryGeneral MedicineColloidchemistryPhotocatalysisGeneral Materials ScienceLayer (electronics)Journal of Materials Chemistry B
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Genotoxic effects of zinc oxide nanoparticles

2015

The potential toxicity of nanoparticles has currently provoked public and scientific discussions, and attempts to develop generally accepted handling procedures for nanoparticles are under way. The investigation of the impact of nanoparticles on human health is overdue and reliable test systems accounting for the special properties of nanomaterials must be developed. Nanoparticular zinc oxide (ZnO) may be internalised through ambient air or the topical application of cosmetics, only to name a few, with unpredictable health effects. Therefore, we analysed the determinants of ZnO nanoparticle (NP) genotoxicity. ZnO NPs (15-18 nm in diameter) were investigated at concentrations of 0.1, 10 and …

Materials scienceCell SurvivalDNA damageMetal Nanoparticleschemistry.chemical_elementNanoparticleNanotechnologyZincmedicine.disease_causechemistry.chemical_compoundChloridesMicroscopy Electron TransmissionCell Line TumormedicineHumansDNA Breaks Double-StrandedGeneral Materials ScienceAcetylcysteinechemistryZinc CompoundsCell cultureToxicityBiophysicsZinc OxideReactive Oxygen SpeciesDNAGenotoxicityIntracellularNanoscale
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Proteomic identification of the heterogeneous nuclear ribonucleoprotein K as irradiation responsive protein related to migration

2014

Abstract Irradiation resistance is a major obstacle of head and neck squamous cell carcinoma (HNSCC) therapy, limiting treatment success and patient survival. The aim of our experiments was to identify irradiation-regulated proteins as potential drug targets. Two established HNSCC cell lines (HNSCCUM-01T and HNSCCUM-02T) were treated with a single 8 Gy (Gray) fraction of irradiation. Changes in cellular protein expression were studied after 24 h by means of 2D-electrophoresis and MALDI–TOF-mass spectrometry. Ninety-four differentially expressed proteins were identified. The expression levels of four proteins were regulated similarly in both cell lines after irradiation treatment, i.e., GRP7…

ProteomicsBiophysicsBiologyBiochemistryCellular proteinImmunocytochemical stainingHeterogeneous-Nuclear Ribonucleoprotein KCell MovementCell Line TumormedicineHumansHeterogeneous-Nuclear Ribonucleoprotein KIrradiationNeoplasm MetastasisEndoplasmic Reticulum Chaperone BiPmedicine.diseaseMolecular biologyHead and neck squamous-cell carcinomaNeoplasm ProteinsGene Expression Regulation NeoplasticBlotRibonucleoproteinsGamma RaysHead and Neck NeoplasmsBiological significanceCell cultureCarcinoma Squamous CellCancer researchJournal of Proteomics
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