0000000000874865

AUTHOR

Jerome Etienne

showing 2 related works from this author

Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease

2002

ABSTRACT The expression of most Staphylococcus aureus virulence factors is controlled by the agr locus, which encodes a two-component signaling pathway whose activating ligand is an agr -encoded autoinducing peptide (AIP). A polymorphism in the amino acid sequence of the AIP and of its corresponding receptor divides S. aureus strains into four major groups. Within a given group, each strain produces a peptide that can activate the agr response in the other member strains, whereas the AIPs belonging to different groups are usually mutually inhibitory. We investigated a possible relationship between agr groups and human S. aureus disease by studying 198 S. aureus strains isolated from 14 asym…

[SDE] Environmental SciencesStaphylococcus aureus[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT][SDV]Life Sciences [q-bio]Bacterial ToxinsImmunologyVirulenceLocus (genetics)Biologymedicine.disease_causeMicrobiologylaw.inventionMicrobiology03 medical and health sciencesBacterial ProteinslawPhylogeneticsmedicineHumansAllelePeptide sequenceComputingMilieux_MISCELLANEOUSAllelesPhylogenyPolymerase chain reaction030304 developmental biologyGenetics0303 health sciencesVirulence030306 microbiologyBacterial InfectionsStaphylococcal Infectionsbiochemical phenomena metabolism and nutritionbacterial infections and mycoses[SDV] Life Sciences [q-bio]Infectious DiseasesPOUVOIR PATHOGENEStaphylococcus aureus[SDE]Environmental SciencesTrans-ActivatorsbacteriaFemaleParasitologyAmplified fragment length polymorphismSignal Transduction
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Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia

2019

International audience; Objectives - Time to blood culture positivity (TTP), a routinely available parameter in automated blood culture systems, may be a proxy for infectious burden in patients with bloodstream infections. We aimed to study the association between TTP and infective endocarditis (IE), or death, in patients with Staphylococcus aureus bacteraemia. Methods - VIRSTA is a multicenter prospective cohort study that included all adult patients with S. aureus bacteraemia in eight university hospitals in France (2009-2011). We analyzed data from four centers which collected data on TTP. Regression models were used to study the association between TTP and definite IE (Duke-Li criteria)…

MaleMethicillin-Resistant Staphylococcus aureus0301 basic medicineMicrobiology (medical)Staphylococcus aureusbacteraemiamedicine.medical_specialtyTime FactorsMultivariate analysis030106 microbiologyBacteremiaIndependent predictormedicine.disease_cause03 medical and health sciences0302 clinical medicineInterquartile rangehemic and lymphatic diseasesInternal medicinemedicineHumansBlood cultureProspective Studies030212 general & internal medicinetime to blood culture positivityProspective cohort study[SDV.MP] Life Sciences [q-bio]/Microbiology and ParasitologyAgedmedicine.diagnostic_testinfective endocarditisbusiness.industryEndocarditis BacterialGeneral MedicineMiddle AgedStaphylococcal Infectionsrespiratory systemmedicine.diseasemortality3. Good health[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyInfectious DiseasesQuartileBlood CultureStaphylococcus aureusInfective endocarditisFemalebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyClinical Microbiology and Infection
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