Author: Sagnelli Evangelista

0000000000875697

AUTHOR

Sagnelli Evangelista

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Gender differences in chronic HBsAg carriers in Italy: Evidence for the independent role of male sex in severity of liver disease

2015

It has been shown that sexual hormones have an opposite effect on hepatic fibrosis progression and hepatocellular carcinoma development. Sex differences among 2,762 chronic HBsAg carriers consecutively referring Italian hospitals in 2001 and in 2007 have been evaluated, particularly focusing on the role of gender on severity of liver disease. The overall sex ratio (males/females) was 2.6. Females were more likely born abroad and new diagnosis cases; but less likely HIV coinfected. No sex difference was observed regarding coinfection with other hepatitis viruses. The sex ratio linearly increased with increasing severity of liver disease, being 1.3 in normal ALT, 2.8 in chronic hepatitis, 3.6…

Liver CirrhosisAdultMaleChronic HBsAg carriers; Cirrhosis; Hepatocellular carcinoma; Sex differences; Adult; Aged; Carcinoma Hepatocellular; Female; Hepatitis B Surface Antigens; Hepatitis B Chronic; Humans; Italy; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Sex Factors; Virology; Infectious DiseasesCarcinoma HepatocellularHepatocellular carcinomaLiver CirrhosiHepatitis B Surface AntigenChronic HBsAg carriersHepatitis B ChronicSex FactorsVirologySex differencesHumansChronicAgedChronic HBsAg carrierHepatitis B Surface AntigensCirrhosiCarcinomaLiver NeoplasmsHepatocellularMiddle AgedHepatitis BSex differenceInfectious DiseasesCirrhosisItalyLiverLiver NeoplasmFemaleHuman

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