Expression of chemokine receptor CXCR3, CXCR4, and CXCR7 and their respective ligands in rhabdomyosarcoma

Papel de las quimiocinas en la progresión del melanoma

Resumen Las metastasis son la principal causa de mortalidad en el melanoma. Las quimiocinas son citocinas quimiotacticas de bajo peso molecular que permiten la migracion celular, atrayendo a celulas que expresan sus receptores. Como algunas quimiocinas son abundantes en organos que son asiento comun de metastasis, y sus receptores son expresados por las celulas tumorales, se planteo la hipotesis de que un gradiente de estas quimiocinas facilitaria selectivamente las metastasis a esos organos. El hallazgo posterior de la produccion de estas quimiocinas por las propias celulas tumorales, y su efecto autocrino, obliga a modular esta hipotesis. Ademas, muchas quimiocinas tienen efectos contrapu…

Role of Chemokines in Melanoma Progression

Metastasis is the main cause of death from melanoma. Chemokines are low molecular weight chemotactic cytokines that facilitate cellular migration. Thus, cells that express receptors for a given chemokine are attracted to the site of its production. As certain chemokines are found in abundance in organs that are common targets of metastasis and receptors for these chemokines are expressed by tumor cells, it was hypothesized that chemokine gradients might selectively facilitate metastasis to these organs. A later finding that these chemokines were produced by tumor cells, with evidence of autocrine effects, obliged the modification of that hypothesis. Many chemokines are also known to have op…

Chromosomal and genetic changes produced in tumoral progression of embryonal rhabdomyosarcoma