0000000000881385

AUTHOR

Anis Khan

showing 2 related works from this author

Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus.

2021

This article also appears in: Health, Medical, and Life Sciences Virtual Issue for Advanced Science.

FGF21General Chemical EngineeringGeneral Physics and AstronomyMedicine (miscellaneous)CODON USAGE BIAS02 engineering and technology01 natural sciencesGLUCOSEACTIVATIONPF-05231023ComputingMilieux_COMPUTERSANDEDUCATIONGeneral Materials SciencegeneticsCells CulturedINSULIN-RESISTANCEFull PaperFatty liverQGeneral Engineeringfibroblast growth factor 21 genetics metabolic metabolic associated fatty liver disease Cells Cultured Enzyme-Linked Immunosorbent Assay Fatty Liver Fibroblast Growth Factors Humans Inflammation LiverFull Papers021001 nanoscience & nanotechnologyPhenotype3. Good healthLiverOBESITY221 Nano-technology0210 nano-technologyReprogrammingEXPRESSIONmedicine.medical_specialtySettore MED/12 - GASTROENTEROLOGIAScienceEnzyme-Linked Immunosorbent Assayfibroblast growth factor 21Biology010402 general chemistryBiochemistry Genetics and Molecular Biology (miscellaneous)metabolic associated fatty liver diseaseInsulin resistancemetabolicInternal medicinemedicineHumansSecretionFGF21 RESISTANCEAlleleInflammationmedicine.disease0104 chemical sciencesFatty LiverFibroblast Growth FactorsEndocrinologyRNA SECONDARY STRUCTURETRANSLATIONHormoneAdvanced science (Weinheim, Baden-Wurttemberg, Germany)
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A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B

2018

Background Host genetic modifiers of the natural history of chronic hepatitis B (CHB) remain poorly understood. Recently, a genome-wide association study (GWAS)-identified polymorphism in the STAT4 gene that contributes to the risk for hepatocellular carcinoma (HCC) was shown to be associated with the full spectrum of hepatitis B virus (HBV) outcomes in Asian patients. However, the functional mechanisms for this effect are unknown and the role of the variant in modulating HBV disease in Caucasians has not been investigated. Aims To determine whether STAT4 genetic variation is associated with liver injury in Caucasian patients with CHB and to investigate potential mechanisms mediating this e…

musculoskeletal diseases0301 basic medicinemedicine.medical_specialtyGenome-wide association studymedicine.disease_cause03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingimmune system diseasesInternal medicinemedicineGenetic predispositionPharmacology (medical)skin and connective tissue diseasesHepatitis B virusHepatologybusiness.industryGastroenterologyhemic and immune systemsHepatologyHepatitis Bmedicine.disease030104 developmental biologyHepatocellular carcinomaImmunologyInterleukin 12030211 gastroenterology & hepatologyViral hepatitisbusinessAlimentary Pharmacology & Therapeutics
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