0000000000888460
AUTHOR
M Bock
showing 2 related works from this author
Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium
2017
AbstractBarrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and the molecular mechanisms responsible for the change in cellular phenotype are poorly understood. We therefore explored the role of two transcription factors, Cdx2 and HNF4α in the conversion using primary organ cultures. Biopsy samples from cases of human Barrett's metaplasia were analysed for the presence of CDX2 and HNF4α. A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4α were ectopically expressed by adenoviral infe…
A critical discussion of the electromagnetic radiation (EMR) method to determine stress orientations within the crust
2012
Abstract. In recent years, the electromagnetic radiation (EMR) method has been used to detect faults and to determine main horizontal stress directions from variations in intensities and directional properties of electromagnetic emissions, which are assumed to be generated during micro-cracking. Based on a large data set taken from an area of about 250 000 km2 in Northern Germany, Denmark, and southern Sweden with repeated measurements at one location during a time span of about 1.5 yr, the method was systematically tested. Reproducible observations of temporary changes in the signal patterns, as well as a strongly concentric spatial pattern of the main directions of the magnetic component …