0000000000889122

AUTHOR

Susan A. Rotenberg

showing 3 related works from this author

Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo

2015

Following recent work on heterometallic titanocene-gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis, characterization and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = S-C6H4-COO-) bound to gold(I)-phosphane fragments through a thiolate group ([(η-C5H5)2TiMe(μ-mba)Au(PR3)]. The compounds are more stable in physiological media than those previously reported and are highly cytotoxic against human cancer renal cell lines. We describe here preliminary mechanistic data involving studies on the interaction of selected compounds with plasmid (pBR322) DNA used as a model nucleic acid, and with s…

BiochemistryChemistryKinaseCell cultureIn vivoCancer cellCytotoxic T cellGeneral ChemistryLigand (biochemistry)Protein kinase BIn vitro3. Good healthChemical Science
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Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo † †This paper is dedicated to Prof. Roberto Sánchez-Delgado, g…

2015

Heterometallic compounds as anticancer agents demonstrating in vivo potential for the first time. Titanocene–gold derivatives: promising candidates for renal cancer.

ChemistryChemical Science
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CCDC 1400886: Experimental Crystal Structure Determination

2015

Related Article: Jacob Fernández-Gallardo, Benelita T. Elie, Tanmoy Sadhukha, Swayam Prabha, Mercedes Sanaú, Susan A. Rotenberg, Joe W. Ramos, María Contel|2015|Chemical Science|6|5269|doi:10.1039/C5SC01753J

Space GroupCrystallographyCrystal System(4-carboxybenzene-1-thiolato)-((ferrocen-1-yl)(diphenyl)phosphine)-gold(i)Crystal StructureCell ParametersExperimental 3D Coordinates
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