0000000000890473

AUTHOR

Wolfgang Schlumberger

showing 3 related works from this author

Impact of Viral and Bacterial Infectious Burden on Long-Term Prognosis in Patients With Coronary Artery Disease

2001

Background —The number of infectious pathogens to which an individual has been exposed (infectious burden) may correlate with coronary artery disease (CAD). In a prospective study, we evaluated the effect of 8 pathogens and the aggregate pathogen burden on the risk for future fatal cardiac events among patients with angiographically documented CAD. Methods and Results —In 1018 patients, IgG or IgA antibodies to herpes simplex virus types 1 and 2, cytomegalovirus, Epstein-Barr virus, Haemophilus influenzae , Chlamydia pneumoniae , Mycoplasma pneumoniae , and Helicobacter pylori were determined. Moreover, highly sensitive C-reactive protein was measured. Follow-up information on cardiovascul…

MaleHuman cytomegalovirusHerpesvirus 4 Humanmedicine.medical_specialtyHerpesvirus 2 HumanCytomegalovirusCoronary DiseaseComorbidityHerpesvirus 1 HumanAntibodies Viralmedicine.disease_causeRisk AssessmentHerpesviridaeCoronary artery diseaseSeroepidemiologic StudiesBetaherpesvirinaePhysiology (medical)Internal medicineOdds RatiomedicineHumansProspective cohort studyHelicobacter pyloribiologybusiness.industryBacterial InfectionsOdds ratioChlamydophila pneumoniaeMiddle AgedPrognosismedicine.diseasebiology.organism_classificationAntibodies BacterialHaemophilus influenzaeComorbidityMycoplasma pneumoniaeC-Reactive ProteinVirus DiseasesImmunoglobulin GChlamydialesImmunologyFemaleCardiology and Cardiovascular MedicinebusinessFollow-Up StudiesCirculation
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Impact of infectious burden on extent and long-term prognosis of atherosclerosis.

2002

Background — Recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. In hypothesizing an association between infectious agents and the development of atherosclerosis, we would expect a correlation to the extent of atherosclerosis. Moreover, this effect could be multiplied by the number of pathogens to which an individual had been exposed. Methods and Results — In 572 patients, IgG or IgA antibodies to herpes simplex virus 1 and 2, cytomegalovirus, Epstein-Barr virus, Hemophilus influenzae , Chlamydia pneumoniae , Mycoplasma pneumoniae , and Helicobacter pylori were measured. The extent of atherosclerosis was determined by coronary angiography, carotid…

Human cytomegalovirusMalemedicine.medical_specialtyHerpesvirus 4 HumanTime FactorsArteriosclerosisCarotid arteriesCytomegalovirusCoronary diseasemedicine.disease_causeAntibodies ViralHerpesviridaePathogenesisRisk FactorsPhysiology (medical)medicineHumansSimplexvirusIntensive care medicineAgedHelicobacter pyloribusiness.industryBacterial InfectionsChlamydophila pneumoniaeMiddle Agedmedicine.diseasePrognosisAntibodies BacterialHaemophilus influenzaeSurvival AnalysisDNA Virus InfectionsImmunoglobulin AMycoplasma pneumoniaeSurvival RateC-Reactive ProteinLogistic ModelsHerpesvirus hominisImmunoglobulin GImmunologyMultivariate AnalysisVirusesFemaleCardiology and Cardiovascular MedicinebusinessCirculation
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Impact of infectious burden on progression of carotid atherosclerosis.

2002

Background and Purpose— Recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. The extent of atherosclerosis and the prognosis of patients with atherosclerosis seem to be increased by the number of infections to which an individual has been exposed. In a prospective study, we evaluated the effect of 8 pathogens and the aggregate pathogen burden on the progression of carotid atherosclerosis. Methods— In 504 patients (74.9% men; age, 62.9±10 years), we measured intima-media thickness and prevalence of carotid artery stenosis. Follow-up measurements after a mean of 2.5 years were available in 427 patients (85%). Blood samples were taken, and IgG or IgA …

Carotid Artery DiseasesMalemedicine.medical_specialtyMycoplasma pneumoniaePathologyEpstein-Barr Virus InfectionsStatinHaemophilus Infectionsmedicine.drug_classComorbiditymedicine.disease_causeAntibodies ViralInfectionsGastroenterologyVirusHelicobacter InfectionsSeroepidemiologic StudiesInternal medicineGermanymedicineOdds RatioPrevalenceHumansMycoplasma InfectionsProspective StudiesProspective cohort studyChlamydophila InfectionsUltrasonographyAdvanced and Specialized NursingChlamydiaVascular diseasebusiness.industryHerpes SimplexOdds ratioMiddle Agedmedicine.diseaseAntibodies BacterialImmunoglobulin AHerpes simplex virusCarotid ArteriesImmunoglobulin GCytomegalovirus InfectionsDisease ProgressionFemaleNeurology (clinical)Cardiology and Cardiovascular MedicinebusinessTunica IntimaTunica MediaStroke
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