0000000000890505

AUTHOR

M. A. Broda

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Conformational properties of N′,N′-dimethylamides of N-acetyldehydroalanine and N-acetyl-(Z)-dehydrophenylalanine

2001

Conformational preferences of Ac-deltaAla-NMe2 and Ac-(Z)-deltaPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly conservative conformation of the dehydro dimethylamides, which is located in a high-energy region of the Ramachandran map.

N¢-dimethylamidesaalanine and phenylalaninederivativesb-dehydroamino acidsGeneral Biochemistry Genetics and Molecular BiologyX-ray crystallographytheoretical calculations
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