6533b83afe1ef96bd12a7a28
RESEARCH PRODUCT
Conformational properties of N′,N′-dimethylamides of N-acetyldehydroalanine and N-acetyl-(Z)-dehydrophenylalanine
Dawid SiodłakM. A. BrodaB. RzeszotarskaA. E. KoziołI. Dybałasubject
N¢-dimethylamidesaalanine and phenylalaninederivativesN¢b-dehydroamino acidsGeneral Biochemistry Genetics and Molecular BiologyX-ray crystallographytheoretical calculationsdescription
Conformational preferences of Ac-deltaAla-NMe2 and Ac-(Z)-deltaPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly conservative conformation of the dehydro dimethylamides, which is located in a high-energy region of the Ramachandran map.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-12-31 |