0000000000895288
AUTHOR
S. Persson
Calcitonin gene related peptide gene expression in collagen-induced arthritis
On a evalue par hybridation in situ semi-quantitative les variations de l'expression genique du peptide lie au gene de la calcitonine (CGRP) dans les motoneurones spinaux et dans les ganglions des racines dorsales (GRD) de rats chez lesquels l'arthrite a ete induite par l'administration de collagene II (AIC). On a examine les effets d'un traitement systemique avec le corticosteroide budesonide sur l'expression basale du CGRP ainsi que sur ses variations dans des conditions d'inflammation. Dans les GRD, l'AIC a induit une augmentation significative des taux d'ARNm du CGRP. Le budesonide a reduit les taux d'ARNm du CGRP constitutif de ces GRD comparativement a ceux des rats temoins non traite…
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.
Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for…