A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
International audience; So far, no common environmental and/or phenotypic factor has been associated with melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun exposure, pigmentation and nevus phenotypes; risk factors associated with RCC include smoking, obesity and hypertension. A recent study of coexisting melanoma and RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia-associated transcription factor (MITF) has been proposed to act as a melanoma oncogene; it also stimulates the transcription of hypoxia inducible factor (HIF1A), the pathway of which is targeted by kidney canc…
Emissivity measurements of several soils and vegetation types in the 8–14, μm Wave band: Analysis of two field methods
Abstract The two variants of the box method (with one and two lids) has been rigorously analyzed. As a result of this analysis, a correction factor that takes into account the nonideality of the materials used for the box, as well as its geometry, has been derived A simple method for determining the effective downward atmospheric temperature that uses only the temperature measurement at the zenith also has been proposed. Finally, by using one of the two variants of the box method, 72 in situ emissivity measurements in the 8–14 pin wave-band region of typical vegetation, soils, and rocks of Europe and South America, has been obtained. The use of these data for the ernissivity correction of s…