0000000000895451

AUTHOR

C. Lemoine

showing 3 related works from this author

Presence on a human melanoma of multiple antigens recognized by autologous CTL.

1989

We derived from blood lymphocytes of a melanoma patient a large number of cytolytic T-cell clones directed against a cell line of the autologous tumor. Three distinct groups of antigens were recognized by these CTL on the autologous melanoma cells: group A consisted of stable antigens present on all sublines, whereas antigens B and C appeared unstable and were expressed by distinct sublines. In vitro immunoselections with various anti-A CTL clones were applied to the melanoma cells and variants resistant to 3 different CTL clones were obtained. These variants remained sensitive to other anti-A CTL clones, indicating that group A comprises at least 4 different antigens (D, E, F and A'). From…

Cancer ResearchCellular immunitySkin NeoplasmsLymphocyteGenes MHC Class IHuman leukocyte antigenBiologyCell LineAntigenAntigens NeoplasmHLA AntigensmedicineTumor Cells CulturedHumansPan-T antigensMelanomaMelanomaGenetic Variationmedicine.diseaseClone CellsGene Expression Regulation NeoplasticCytolysisCTL*medicine.anatomical_structureOncologyImmunologyLymphocyte Culture Test MixedT-Lymphocytes CytotoxicInternational journal of cancer
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ALEPH: a Detector for Electron-Positron Annihilations at LEP

1990

Process-centred Software Engineering Environments (PSEE) are the most recent generation of environments supporting software development activities. Most of PSEE are based on mechanisms promoting enforcement and automation of process activities. In this kind of mechanisms the process models are prescribed in a detailed and complete way. But the experience shows that supporting processes is more concerned with the flexibility of guidance offered during the process performance than with enforcement of a collection of predefined process models. In this paper, we present a solution to support strategic processes in a PSEE by providing a flexible guidance during process enactment.

PhysicsFlexibility (engineering)Nuclear and High Energy PhysicsAlephhigh-energy physicsProcess modelingProcess (engineering)business.industrySoftware developmentLEPAutomationparticle detectorsData acquisitionDetectors and Experimental TechniquesLEP; particle detectors; high-energy physicsSoftware engineeringbusinessEnforcementInstrumentationparticle detector
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Production of stable cytolytic T-cell clones directed against autologous human melanoma

1987

We have attempted to optimize the production of stable human cytolytic T lymphocyte clones directed against autologous melanoma cell lines. MLTC were restimulated every week with irradiated melanoma cells in medium containing human serum and IL-2. After 21 to 35 days, in 5 out of 6 patients, these cultures expressed a preferential cytolytic activity against the autologous melanoma cells, as compared to autologous EBV-B cells or NK target K562. Limiting dilution of MLTC responder cells was performed at times varying from days 7 to 28, in medium containing IL-2 and allogeneic EBV-B cells as feeders. Approximately 1% of these responder cells gave rise to CTL clones that lysed the autologous me…

Cancer ResearchSkin NeoplasmsLysisbusiness.industryT cellMelanomaT lymphocytemedicine.diseaseAutoantigensCell LineClone CellsCytolysisCTL*medicine.anatomical_structureOncologyAntigenAntigens NeoplasmImmunologyCancer researchHumansMedicinebusinessMelanomaT-Lymphocytes CytotoxicK562 cellsInternational Journal of Cancer
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