0000000000899400
AUTHOR
Rosalia Savona
showing 17 related works from this author
Implication of specific isoforms of p38 in termothollerance and in the response to different stresses in sea urchin embryo
2005
MAPK activation is required for Paracentrotus lividus skeletogenesis
2008
P38 MAPK expression during development and in stress response in sea urchin embryo
2007
P38 MAPK plays a key role in skeletogenesis of Paracentrotus lividus embryo
2006
Espressione basale dell’HSP70 inducibile in differenti linee staminali di topo.
2004
Effect of cadmium on MDA-MB231 breast cancer cells
2006
We demonstrated that treatment of estrogen receptor-negative (ER-) MDA-MB231 breast cancer cells with 5 M Cd for 96h resulted in an about 50% reduction of cell number
Nickel, lead, and cadmium induce differential cellular responses in sea urchin embryos by activating the synthesis of different HSP70s.
2004
Treatment with heavy metals, such as nickel, lead or cadmium, elicits different cellular stress responses according to the metal used and the length of treatment. In Paracentrotus lividus embryos the inducible forms of HSP70 (HSP70/72) are different in molecular mass from the constitutively expressed HSP75, and they can be used as markers of cellular stress. Even a short treatment with each metal induces the synthesis of HSP70/72 which remain stable for at least 20 h and differ little in their isoelectric points. Continuous treatment from fertilization with nickel or lead produces late irregular pluteus embryos, with peak HSP70/72 synthesis at blastula followed by the arrest of synthesis by…
Implication of p38 MAPK in skeletogenesis of Paracentrotus lividus embryo
2006
Different Kind of stress activate differnt isoforms of p38MAPK in sea urchin embryos
2007
p38 MAPK activity during sea urchin embryo development (Paracentrotus lividus)
2005
Effect of cadmium on MDA-MB231 breast cancer cells
2006
P38 mapk activity during sea urchin embryo development
2006
EFFECT OF CADMIUM ON IMMORTALIZED AND NEOPLASTIC EPITHELIAL CELLS OF THE HUMAN BREAST
2005
Cadmium effect on gene expression by MDA-MB231 breast cancer cells: evidence for down-regulation of AEG-1
2006
p38 MAPK activation is required for Paracentrotus lividus skeletogenesis
2008
We investigated the p38 MAPK role during sea urchin, Paracentrotus lividus, development. We found that at the morula stage, before the onset of skeletogenesis, p38 MAPK shows a peak of activity, and we tested whether p38 MAPK activity has any effect on skeletogenesis. By immunohistochemistry on whole-mount embryos we show the preferential localization of the active p38 form both in the presumptive PMCs and bilateral spiculo- genesis centers in control embryos, and in the radialized supernumerary spiculogenesis centers induced by NiCl2 treatment. By using SB203580, a p38 MAPK specific inhibitor, we show that p38 activity is required both for the initial triradiate spicule rudiments formation…