The sensitization of HepG2 and HT29 cells to TRAIL-induced apoptosis by histone deacetylase inhibitors is mediated by down-regulation of AKT and NF-kB.

Parthenolide sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis

Synergistic interaction between Parthenolide and TRAIL induces apoptosis in human hepatocarcinoma cells.

Partenolide, a natural compound used in traditional medicine for its anti-inflammatory activity, has recently shown anti-tumor and apoptotic effects. Our studies demonstrated that HepG2; Hep3B and SK-Hep1 hepatocarcinoma cells, which are resistant to human recombinant TRAIL, are potently sensitized to TRAIL-induced apoptosis by low doses of parthenolide resulting in a marked synergist effect. To clarify the mechanism that accounts for this interaction, we demonstrated that parthenolide/TRAIL combination markedly increased DR4 and DR5. These effects might be correlated with STAT proteins modifications. In fact parthenolide and parthenolide/TRAIL combination decreased STAT3 and STAT5 and thei…

CELL CULTURES

IL TRATTAMENTO COMBINATO SAHA/TRAIL INDUCE IN CELLULE DI CARCINOMA MAMMARIO MDA-MB231 IL DISTACCO E LA MORTE PER ANOIKIS

Cell Viability

Il partenolide sensibilizza le cellule di epatocarcinoma all'apoptosi indotta da TRAIL

TWO-DIMENSIONAL ANALYSIS OF PROTEIN EXPRESSION PATTERNS