0000000000899659

AUTHOR

Anna Ciraolo

showing 8 related works from this author

The sensitization of HepG2 and HT29 cells to TRAIL-induced apoptosis by histone deacetylase inhibitors is mediated by down-regulation of AKT and NF-k…

2008

Hepatoma cells TRAIL HDACI
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Parthenolide sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis

2009

parthenolide HCC DR4 STAT-3Settore BIO/10 - Biochimica
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Synergistic interaction between Parthenolide and TRAIL induces apoptosis in human hepatocarcinoma cells.

2009

Partenolide, a natural compound used in traditional medicine for its anti-inflammatory activity, has recently shown anti-tumor and apoptotic effects. Our studies demonstrated that HepG2; Hep3B and SK-Hep1 hepatocarcinoma cells, which are resistant to human recombinant TRAIL, are potently sensitized to TRAIL-induced apoptosis by low doses of parthenolide resulting in a marked synergist effect. To clarify the mechanism that accounts for this interaction, we demonstrated that parthenolide/TRAIL combination markedly increased DR4 and DR5. These effects might be correlated with STAT proteins modifications. In fact parthenolide and parthenolide/TRAIL combination decreased STAT3 and STAT5 and thei…

Parthenolide HCC TRAILSettore BIO/10 - Biochimica
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CELL CULTURES

2008

Settore BIO/10 - BiochimicaMethodological approaches CELL CULTURES viability measurements
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IL TRATTAMENTO COMBINATO SAHA/TRAIL INDUCE IN CELLULE DI CARCINOMA MAMMARIO MDA-MB231 IL DISTACCO E LA MORTE PER ANOIKIS

2011

Settore BIO/10 - BiochimicaSAHA/TRAILANOIKISCARCINOMA MAMMARIO
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Cell Viability

2008

MTTLDHtrypan blueSettore BIO/10 - Biochimica
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Il partenolide sensibilizza le cellule di epatocarcinoma all'apoptosi indotta da TRAIL

2009

epatocarcinoma TRAIL DR4 DR5 STAT-3.
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TWO-DIMENSIONAL ANALYSIS OF PROTEIN EXPRESSION PATTERNS

2008

PROTEOMIC ANALYSIS ELECTROPHORESISSettore BIO/10 - Biochimica
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