Disseminated Intravascular Coagulation

During the past decade, diffuse intravascular coagulation (DIC) has been one of the most intensively studied subjects in hematology. DIC is a dynamic pathologic process caused by the entrance of foreign material into the circulation, or by exposure to abnormal surfaces. The intravascular coagulation is triggered by activation of the clotting cascade with resultant generation of excess thrombin within the vascular system that leads to further activation of the coagulation system, shortened survival of certain hemostatic elements, deposition of fibrin in the microcirculation, and activation of the fibrinolytic system. Decreased levels of hemostatic factors, secondary fibrinolysis, and exhaust…