0000000000903989

AUTHOR

Domenico Cucinotta

showing 12 related works from this author

Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial

2013

Context: This study was performed to evaluate the effects of genistein on metabolic and cardiovascular risk factors in Caucasian postmenopausal subjects with metabolic syndrome (MetS). Objective: Our objective was to assess the effects of genistein on surrogate endpoints associated with diabetes and cardiovascular disease. Design and Setting: This was a randomized, double-blind, placebo-controlled trial at 3 university medical centers in Italy. Patients: Patients included 120 postmenopausal women with MetS according to modified Third Report of the National Cholesterol Education Program (NCEP), Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Tre…

medicine.medical_specialtyCardiovascular Risk Factorsgenistein aglycone; metabolic syndrome; Cardiovascular Risk FactorsEndocrinology Diabetes and MetabolismClinical BiochemistryContext (language use)PlaceboBiochemistrylaw.inventionEndocrinologyInsulin resistanceDouble-Blind MethodRandomized controlled triallawDiabetes mellitusInternal medicinemedicineHumansgenistein aglyconeNational Cholesterol Education ProgramAgedMetabolic SyndromeSurrogate endpointbusiness.industryMetabolic Syndrome XCholesterol HDLBiochemistry (medical)Cholesterol LDLMiddle Agedmedicine.diseaseGenisteinEndocrinologyFemaleInsulin ResistanceMetabolic syndromebusinessHumanThe Journal of Clinical Endocrinology & Metabolism
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Agreement between different versions of MNA.

2013

Malnutrition occurs frequently in the elderly with important clinical and functional consequences. Moreover, the treatment of malnutrition in the elderly may be effective if clinical and nutritional interventions are performed in the early stages. Therefore the early identification of the risk of malnutrition using validated and handy tools plays a pivotal role in terms of clinical outcome. Mini Nutritional Assessment (MNA) was validated for this purpose since many years but it is still ongoing the debate over whether the use of different items in certain clinical conditions can be effective without affecting the validity of the nutritional status evaluation. The aim of this study was to as…

GerontologyMaleMini nutritional assessmentMEDLINEMedicine (miscellaneous)Nutritional StatuselderlyRisk AssessmentSensitivity and SpecificityBody Mass IndexNutritional InterventionsRisk FactorsSurveys and Questionnairesmedicine80 and overNutrition and DieteticPrevalenceSurveys and QuestionnaireHomes for the AgedHumanselderly; malnutrition; MNA; Aged; Aged 80 and over; Body Mass Index; Female; Geriatric Assessment; Humans; Italy; Male; Malnutrition; Nutritional Status; Prevalence; Risk Assessment; Risk Factors; Sensitivity and Specificity; Surveys and Questionnaires; Homes for the Aged; Nursing Homes; Nutrition Assessment; Medicine (miscellaneous); Nutrition and Dietetics; Geriatrics and GerontologyNutritional riskGeriatric AssessmentAgedAged 80 and overNutrition and Dieteticsbusiness.industryRisk FactorMalnutritionNutritional statusmedicine.diseaseNursing HomesMalnutritionNutritional StatuNursing HomeNutrition AssessmentMNAItalymna; elderly; malnutritionFemaleGeriatrics and GerontologybusinessRisk assessmentBody mass indexHumanThe journal of nutrition, healthaging
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Corrigenda

2015

Context: Foot ulcer is the principal cause of hospitalization for patients with diabetes. Polydeoxyribonucleotide (PDRN), an adenosine A2A receptor agonist, improves wound healing in diabetic mice. Objective: The aim of this study was to evaluate the effect of PDRN on chronic ulcer healing in patients with diabetes. Design and Setting: This randomized, double-blind, placebo-controlled trial, involved two medical centers in Italy. Intervention: Patients with diabetes showing hard-to-heal ulcers (Wagner grade 1 or 2) were randomly assigned to receive placebo (n = 106) or PDRN (n = 110). The treatments (PDRN and placebo) were performed 3 days a week for 8 weeks by intramuscular and perilesiona…

Agonistmedicine.medical_specialtymedicine.drug_classbusiness.industryEndocrinology Diabetes and MetabolismBiochemistry (medical)Clinical BiochemistryContext (language use)medicine.diseasePlaceboBiochemistryDiabetic footlaw.inventionSurgeryClinical trialEndocrinologyEndocrinologyRandomized controlled triallawDiabetes mellitusInternal medicineAnesthesiamedicinebusinessWound healingThe Journal of Clinical Endocrinology & Metabolism
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Malnutrition in elderly: Social and economic determinants

2013

Abstract: Malnutrition occurs frequently in the frailest groups of the population, especially in people who are on a low income and elderly subjects, overall if they are institutionalized. The aim of this study was to assess the prevalence of malnutrition in a sample of elderly people living in different settings and to identify the determinants of malnutrition. Methods: A total of 718 subjects, 472 females (F) and 246 males (M), were recruited from nursing homes or were free living in three different regions in Italy. Nutritional status, depression, social, functional and cognitive status, were evaluated. Results: According to the Mini Nutritional Assessment (MNA), a high prevalence of mal…

Low incomeGerontologyMaleSettore MED/09 - Medicina InternapovertyMalnutrition elderly poverty.PopulationNutritional StatusMedicine (miscellaneous)Guidelines as TopicelderlyGeriatric populationRisk Factorspoverty; elderly; malnutrition80 and overPrevalenceElderly peopleMedicineHumanseducationGeriatric AssessmentDepression (differential diagnoses)AgedAged 80 and overeducation.field_of_studyNutrition and Dieteticsbusiness.industryMalnutritionNutritional statuselderly; Malnutrition; poverty; Aged; Aged 80 and over; Female; Geriatric Assessment; Guidelines as Topic; Humans; Italy; Male; Malnutrition; Nursing Homes; Nutrition Assessment; Nutritional Status; Prevalence; Risk Factors; Socioeconomic Factors; Medicine (miscellaneous); Nutrition and Dietetics; Geriatrics and Gerontologymedicine.diseaseNursing HomesMalnutritionNutrition AssessmentItalySocioeconomic FactorsFemaleGeriatrics and GerontologybusinessNursing homes
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Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial …

2015

BACKGROUND: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated.METHODS: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population …

Malemedicine.medical_specialtyAcute coronary syndromePopulationLIXisenatide610 Medicine & healthHypoglycemiaPlacebop38 Mitogen-Activated Protein Kinases11171 Cardiocentro Ticino2705 Cardiology and Cardiovascular Medicinelaw.inventionSettore MED/13 - EndocrinologiaAcute Coronary Syndrome; Aged; Cardiovascular Diseases; Double-Blind Method; Female; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Peptides; Placebos; Protein Kinase Inhibitors; Research Design; p38 Mitogen-Activated Protein Kinases; Cardiology and Cardiovascular MedicinePlacebosLixisenatidechemistry.chemical_compoundRandomized controlled trialDouble-Blind MethodlawGlucagon-Like Peptide 1Internal medicineJournal ArticlemedicineHumansComparative StudyMyocardial infarctionAcute Coronary SyndromeeducationProtein Kinase InhibitorsAgededucation.field_of_studybusiness.industryUnstable anginaResearch Support Non-U.S. Gov'tta3121Middle Agedmedicine.diseaseSurgeryMulticenter StudychemistryCardiovascular DiseasesResearch DesignRandomized Controlled TrialCardiologyFemaleCardiology and Cardiovascular MedicinebusinessPeptides
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Serum ionized magnesium levels in relation to metabolic syndrome in type 2 diabetic patients

2006

Objective: To evaluate circulating serum ionized magnesium (i-Mg) concentrations in patients with type 2 diabetes mellitus, and to investigate its relationship with the components of the metabolic syndrome. Design: cross-sectional study. Setting: Outpatients' service for diabetic patients at the University Hospital of Messina, Italy. Subjects: 290 patients with type 2 diabetes mellitus. Measures of Outcome: Serum i-Mg was measured by ion selective electrode. Age, gender, body mass index (BMI), waist circumference, blood pressure, fasting glucose, HbA1c, HDL cholesterol, triglycerides, and urinary albumin excretion rate (UAER) were considered in the analyses. Patients with hypomagnesemia, de…

Malemedicine.medical_specialtyPlasma triglyceridesMedicine (miscellaneous)Type 2 diabetesplasma triglycerideHypomagnesemiaWaist–hip ratioDiabetes mellitusRisk FactorsInternal medicineDiabetes mellitusBlood plasmamedicineHumansAlbuminuriaMagnesiumTriglyceridesSerum ionized magnesiumAnalysis of VarianceNutrition and DieteticsWaist-Hip Ratiodiabetes mellitubusiness.industryType 2 Diabetes MellitusAlbuminuria; Diabetes mellitus; Metabolic syndrome; Plasma triglycerides; Serum ionized magnesium; Waist circumferenceMiddle Agedmedicine.diseaseMetabolic syndromeCross-Sectional StudiesEndocrinologyDiabetes Mellitus Type 2Waist circumferenceFemaleMetabolic syndromebusinessMagnesium DeficiencyBody mass index
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The place of frailty and vulnerability in the surgical risk assessment: should we move from complexity to simplicity?

2018

Due to aging of the world population, older patients accessing health services are becoming continuously more frequent. This has increased the interest in assessing frailty and vulnerability in all specialties and general medicine. Although the term frailty has been recognized for over 30 years, there is not yet a universally recognized definition, and different care providers assess frailty and vulnerability with dissimilar tools, from very complex to very simple validated scales. Being treated with respect and dignity at the right time and place is the key message, as well as after undergoing a global evaluation both in urgency/emergency and in programmed surgery for all older surgical pa…

AgingSettore MED/09 - Medicina InternaFrail Elderlymedia_common.quotation_subjectVulnerability030204 cardiovascular system & hematologyRisk Assessment03 medical and health sciencesDignity0302 clinical medicineOlder patientsIntervention (counseling)HumansMedicineAging; Frailty; Morbidity; Surgery; Aged; Aged 80 and over; Frail Elderly; Humans; Surgical Procedures Operative; Frailty; Risk Assessment; Aging; Geriatrics and Gerontology030212 general & internal medicineSimplicityAgedmedia_commonAged 80 and overFrailtybusiness.industryWorld populationmedicine.diseaseSurgical riskSurgical Procedures OperativeSurgeryMedical emergencyMorbidityGeriatrics and GerontologybusinessRisk assessmentHuman
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Anorexia and Eating Patterns in the Elderly

2013

Objectives To evaluate the change in eating habits occurring in community- dwelling and institutionalized elderly subjects with senile anorexia. Design Cross- sectional, observational. Setting Community, nursing homes and rehabilitation or acute care facilities in four Italian regions. Participants A random sample of 526 subjects, aged 65 years and older (217 free living individuals, 213 residents in nursing homes, and 93 patients in rehabilitation and acute wards). Measurements All subjects underwent a multidimensional geriatric evaluation of: nutritional status, anthropometric parameters, health and cognitive status, depression, taste, chewing and swallowing function, and some hormones re…

MaleGerontologyAgingAnatomy and PhysiologySettore MED/09 - Medicina InternaEpidemiologyCross-sectional studyEating Disorderslcsh:MedicineAnorexia nervosaFood groupAcute careMedicinelcsh:Sciencemedia_commonAged 80 and overPsychiatryGeriatricsMultidisciplinarydigestive oral and skin physiologyEpidemiology of AgingAnorexiaMental HealthMedicineFemalemedicine.symptomeating pattern; senile anorexia; elderly; malnutritionResearch Articlesenile anorexiamedicine.medical_specialtymedia_common.quotation_subjectmalnutritionAnorexiaelderlyAnorexia aging nutrition malnutritionHumanseating patternBiologyAgedNutritionPopulation Biologybusiness.industrylcsh:RAppetiteFeeding Behaviormedicine.diseaseCross-Sectional StudiesGeriatricslcsh:QObservational studyPhysiological Processesbusiness
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Senile anorexia in acute-ward and rehabilitations settings.

2008

The most common pathological change in eating behaviour among older persons is anorexia, which accounts for a large percent of undernutrition in older adults. The main research aims are to determine, in a sample of acute and rehabilitation elderly subjects, the prevalence of anorexia of aging and the causes most impacting on senile anorexia.Methods: four different Units cooperated to this research study. Patients were recruited from geriatric acute and rehabilitation wards in Italy. Each Research Unit, for the estimation of the prevalence of anorexia in elderly subjects evaluated all the patients aged over 65 recruited from April 2006 to June 2007. Nutritional status, depression, social, fu…

Malemedicine.medical_specialtyAgingmedicine.medical_treatmentHealth StatusMedicine (miscellaneous)Nutritional StatusAnorexiaSwallowingQuality of lifemedicinePrevalenceHumansGeriatric AssessmentDepression (differential diagnoses)AgedAged 80 and overNutrition and DieteticsRehabilitationbusiness.industrydigestive oral and skin physiologyAnthropometrymedicine.diseaseComorbidityAnorexiaMalnutritionC-Reactive ProteinNutrition AssessmentCase-Control StudiesPhysical therapyQuality of LifeFemaleGeriatrics and Gerontologymedicine.symptombusinessThe journal of nutrition, healthaging
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Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study

2018

Purpose: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. Methods: We studied 2573 men and women aged 50–75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Ph…

0301 basic medicineMaleAge BMI Diabetes Diet Flavonoids Food groups Geographical area Intake Phenolic acids Polyphenols TOSCA.IT study Aged Antioxidants Beverages Cinnamates Cohort Studies Cross-Sectional Studies Databases Factual Diabetes Mellitus Type 2 Female Flavonoids Fruit Glycosides Humans Italy Male Middle Aged Nutritive Value Phenols Polyphenols Diet Diabetic Diet Healthy Patient ComplianceSettore MED/09 - Medicina InternaDatabases FactualCross-sectional studyMedicine (miscellaneous)Type 2 diabetesDiabeteAntioxidantsSettore MED/13 - EndocrinologiaFood groupCohort Studies0302 clinical medicineDiet DiabeticMedicineFood scienceGlycosidesAge; BMI; Diabetes; Diet; Flavonoids; Food groups; Geographical area; Intake; Phenolic acids; Polyphenols; TOSCA.IT study; Medicine (miscellaneous); Nutrition and DieteticsNutrition and DieteticsPhenolic acidDiabetesfood and beveragesMiddle AgedPolyphenols Flavonoids Phenolic acids Diabetes Food groups Diet Age BMI Geographical area Intake TOSCA.IT studyItalyToscaAgeBMIDiabetesDietFlavonoidsFood groupsGeographical areaIntakePhenolic acidsPolyphenolsTOSCA.IT studyCohortIntakeFemaleDiet HealthyNutritive ValueCohort studyPolyphenolPhenolic acids030209 endocrinology & metabolismBeverages03 medical and health sciencesBMIAgePhenolsDiabetes mellitusHumansAgedFlavonoidsGeographical area030109 nutrition & dieteticsbusiness.industryTOSCA.IT studyPolyphenolsAnthropometrymedicine.diseaseFood groupDietToscaCross-Sectional StudiesDiabetes Mellitus Type 2Food groupsPolyphenolCinnamatesAge; BMI; Diabetes; Diet; Flavonoids; Food groups; Geographical area; Intake; Phenolic acids; Polyphenols; TOSCA.IT studyFruitFlavonoidPatient Compliancebusiness
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Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016

2019

Objective This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods Data were collected during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, only patients enrolled in acute hospital wards were selected (n = 4,133). Delirium was assessed according to score on the 4 "A's" Test. Prescriptions were classified by main drug categories; polypharmacy w…

Malediagnosismedications0302 clinical medicinepreventionAged 80 and over; Delirium; Drug Prescriptions; Female; Hospital Departments; Humans; Male; Prevalence; Polypharmacy; Prescription Drugs80 and overPrevalenceMedicineLS4_4030212 general & internal medicineAcute hospitalmedia_commonAged 80 and overConfoundingelderly patients hip fracture hospitalized patients prediction rule risk factor dementia events medications prevention diagnosisrisk-factorrisk factorhip fracturePsychiatry and Mental HealthFemalemedicine.symptomeventsDrugmedicine.medical_specialtyPrescription Drugshospitalized-patientsmedia_common.quotation_subjectMEDLINEHospital DepartmentsSocio-culturaleelderly-patientselderly patientsbehavioral disciplines and activitiesDrug Prescriptions03 medical and health sciencesInternal medicinemental disordersDementiaHumansMedical prescriptionprediction ruleAgedPolypharmacybusiness.industryhospitalized patientsDeliriummedicine.diseasenervous system diseasesPolypharmacyDeliriumelderly-patients; hip fracture; hospitalized-patients; prediction rule; risk-factor; dementia; events; medications; prevention; diagnosisbusiness030217 neurology & neurosurgerydementia
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"Delirium Day": a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool

2016

Background To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods This is a point prevalence study (called “Delirium Day”) including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium wa…

MaleCross-sectional studyHospitalized patientsPrevalence0302 clinical medicineSurveys and Questionnaires80 and overOdds RatioPrevalenceMedicine030212 general & internal medicineProspective StudiesProspective cohort studyMulticenterAcute hospital2. Zero hungerAged 80 and overMedicine(all)Medicine (all)Settore BIO/14General Medicine3. Good health4AT; Delirium; Hospital; Multicenter; Prevalence; Aged; Aged 80 and over; Cross-Sectional Studies; Delirium; Female; Humans; Inpatients; Italy; Logistic Models; Male; Odds Ratio; Prevalence; Prospective Studies; Surveys and QuestionnairesItalyFemalemedicine.symptomResearch ArticleRehabilitation hospitalmedicine.medical_specialty4AT; Delirium; Hospital; Multicenter; Prevalence; Aged; Aged 80 and over; Cross-Sectional Studies; Delirium; Female; Humans; Inpatients; Italy; Logistic Models; Male; Odds Ratio; Prevalence; Prospective Studies; Surveys and Questionnaires; Medicine (all)NO03 medical and health sciencesHospital4AT Delirium Hospital Multicenter Prevalence Aged Aged 80 and over Cross-Sectional Studies Delirium Female Humans Inpatients Italy Logistic Models Male Odds Ratio Prevalence Prospective Studies Surveys and Questionnairesmental disordersHumans4ATPsychiatry4AT; Delirium; Hospital; Multicenter; Prevalence;AgedInpatientsbusiness.industryDeliriumOdds ratio4AT; Delirium; Hospital; Multicenter; Prevalence; Medicine (all)Cross-Sectional StudiesLogistic ModelsEmergency medicineDeliriumDelirium; Prevalence; Hospital; Multicenter; 4ATbusiness030217 neurology & neurosurgery
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