6533b829fe1ef96bd128a287
RESEARCH PRODUCT
Corrigenda
Antonino SaittaMaria Eugenio De FeoGiovanni PallioAlessandra BittoMario VaccaroFrancesco SquadritoCorrao SalvatoreLetteria MinutoliGiovanni De CaridiDomenica AltavillaDomenico CucinottaCarmelo SterrantinoVincenzo Arcoracisubject
Agonistmedicine.medical_specialtymedicine.drug_classbusiness.industryEndocrinology Diabetes and MetabolismBiochemistry (medical)Clinical BiochemistryContext (language use)medicine.diseasePlaceboBiochemistryDiabetic footlaw.inventionSurgeryClinical trialEndocrinologyEndocrinologyRandomized controlled triallawDiabetes mellitusInternal medicineAnesthesiamedicinebusinessWound healingdescription
Context: Foot ulcer is the principal cause of hospitalization for patients with diabetes. Polydeoxyribonucleotide (PDRN), an adenosine A2A receptor agonist, improves wound healing in diabetic mice. Objective: The aim of this study was to evaluate the effect of PDRN on chronic ulcer healing in patients with diabetes. Design and Setting: This randomized, double-blind, placebo-controlled trial, involved two medical centers in Italy. Intervention: Patients with diabetes showing hard-to-heal ulcers (Wagner grade 1 or 2) were randomly assigned to receive placebo (n = 106) or PDRN (n = 110). The treatments (PDRN and placebo) were performed 3 days a week for 8 weeks by intramuscular and perilesional route. Main Outcome Measures: The primary outcome was complete ulcer healing. Secondary outcomes were the days needed to complete wound closure and the reepithelialization of wound surface (as percentage of the original area). Results: After 8 weeks, 91 placebo and 101 PDRN subjects completed the study. Complete heali...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-02-01 | The Journal of Clinical Endocrinology & Metabolism |