showing 2 related works from this author
Glycation alters ligand binding, enzymatic, and pharmacological properties of human albumin.
2015
Albumin, the major circulating protein in blood plasma, can be subjected to an increased level of glycation in a diabetic context. Albumin exerts crucial pharmacological activities through its drug binding capacity, i.e., ketoprofen, and via its esterase-like activity, allowing the conversion of prodrugs into active drugs. In this study, the impact of the glucose-mediated glycation on the pharmacological and biochemical properties of human albumin was investigated. Aggregation product levels and the redox state were quantified to assess the impact of glycation-mediated changes on the structural properties of albumin. Glucose-mediated changes in ketoprofen binding properties and esterase-lik…
016: Evidence of systemic plaque vulnerability in acute coronary syndromes with FDG-positron emission tomography and computed tomographic angiography…
2013
PurposeAtherosclerotic plaque vulnerability is a systemic phenomenon and is often associated with severe plaque infiltration with inflammatory cells. 18-Fluoro-deoxyglucose (FDG) accumulates in inflammatory cells of atherosclerotic plaques. The aim of this study was to assess whether 1) FDG uptake in the aorta and carotid arteries measured by positron emission tomography (PET) is higher in patients with acute coronary syndromes (ACS) than in patients with stable coronary artery disease (CAD) and; 2) associated with morphological markers of plaque instability detected with computed tomography angiography (CTA).MethodsPatients with ACS (n=50) or stable CAD (n=28) underwent a PET 90 minutes af…