0000000000905435

AUTHOR

Rachael I. Scahill

0000-0002-1832-106x

showing 1 related works from this author

Mapping the onset and progression of atrophy in familial frontotemporal lobar degeneration

2005

Background: Frontotemporal lobar degeneration (FTLD) may be inherited as an autosomal dominant disease. Studying patients "at risk" for developing FTLD can provide insights into the earliest onset and evolution of the disease. Method: We carried out approximately annual clinical, MRI, and neuropsychological assessments on an asymptomatic 51 year old "at risk" family member from a family with FTLD associated with ubiquitin-positive and tau-negative inclusion bodies. We used non-linear (fluid) registration of serial MRI to determine areas undergoing significant regional atrophy at different stages of the disease. Results: Over the first 26 months of the study, the patient remained asymptomati…

PaperMalePathologymedicine.medical_specialtyDiseaseNeuropsychological TestsAsymptomaticBrain mappingAtrophy Brain/pathology Brain Mapping Dementia/pathology Disease Progression Female Follow-Up Studies Humans Male Middle Aged Neuropsychological TestsAtrophymental disordersmedicineHumansDementiaBrain MappingSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaNeuropsychologyfood and beveragesnutritional and metabolic diseasesBrainAutosomal dominant traitFrontotemporal lobar degenerationMiddle Agedmedicine.diseasenervous system diseasesPsychiatry and Mental healthDisease ProgressionDementiaFemaleSurgeryNeurology (clinical)Atrophymedicine.symptomPsychologyFollow-Up Studies
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