0000000000905615

AUTHOR

Christian Wunder

showing 2 related works from this author

Inhibition of Proteasomal Glucocorticoid Receptor Degradation Restores Dexamethasone-Mediated Stabilization of the Blood–Brain Barrier After Traumati…

2013

To establish the molecular background for glucocorticoid insensitivity, that is, failure to reduce edema formation and to protect blood-brain barrier integrity after acute traumatic brain injury.Controlled animal study.University research laboratory.Male C57Bl/6N mice.Mechanical brain lesion by controlled cortical impact.Our study demonstrates that 1) proteasomal glucocorticoid receptor degradation is established in brain endothelial cells after traumatic brain injury as a form of posttranslational glucocorticoid receptor modification; 2) inhibition of the proteasomal degradation pathway with bortezomib (0.2 mg/kg) in combination with the glucocorticoid dexamethasone (10 mg/kg) by subcutane…

MaleProteasome Endopeptidase ComplexTraumatic brain injuryBlotting WesternBrain EdemaPharmacologyReal-Time Polymerase Chain ReactionCritical Care and Intensive Care MedicineBlood–brain barrierSensitivity and SpecificityDexamethasoneStatistics NonparametricBortezomibMiceRandom AllocationReceptors GlucocorticoidGlucocorticoid receptorReference ValuesmedicineAnimalsRNA MessengerReceptorDexamethasonebusiness.industryBortezomibmedicine.diseaseBoronic AcidsImmunohistochemistryMice Inbred C57BLBlotDisease Models Animalmedicine.anatomical_structureBlood-Brain BarrierBrain InjuriesPyrazinesMultivariate AnalysisBlood Gas AnalysisbusinessGlucocorticoidmedicine.drugCritical Care Medicine
researchProduct

Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study

2022

PLOS ONE 17(1), e0262110 (2022). doi:10.1371/journal.pone.0262110

Clinical OncologyMaleScienceClinical Decision-MakingCancer TreatmentSurgical and Invasive Medical ProceduresGeographical LocationsDiagnostic MedicineOutcome Assessment Health CareMedicine and Health SciencesHumansBlood TransfusionProspective StudiesAgedAged 80 and overIntraoperative CareMultidisciplinaryTransfusion MedicineQRAnemiaHematologyClinical Laboratory SciencesHealth CareEuropeSurgical OncologyOncologyAge GroupsElective Surgical ProceduresPeople and PlacesMedicinePopulation GroupingsFemaleGeriatric CareClinical MedicineErythrocyte TransfusionResearch ArticlePLOS ONE
researchProduct