0000000000906126
AUTHOR
A. Benani
Redox state alteration modulates astrocyte glucuronidation.
We have investigated the effects of mild oxidative conditions on drug-metabolizing enzyme activity in rat cultured astrocytes. These experimental conditions promoting an oxidative environment were obtained by short exposure to a low concentration of menadione (5 microM) for a short duration (15 min). This resulted in the rapid and transient production of reactive oxygen species (+130%), associated with a decrease in GSH cellular content (-24%), and an increase in total protein oxidation (+26%), but promoted neither PGE(2) nor NO production. This treatment induced a rapid and persistent decrease in astrocyte glucuronidation activities, which was totally prevented by N-acetyl-l-cysteine. Thes…
MOESM5 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 5. List of the 2 and 8 KEGG pathways significantly enriched in the over- and under-expressed genes in the blood.
MOESM3 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 3. List of the differentially expressed genes (LE vs. CT) in each tissue.
MOESM8 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 8. Composition of the diets.
MOESM4 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 4. List of the 26 and 44 KEGG pathways significantly enriched in the over- and under-expressed genes in the hypothalamus.
MOESM7 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 7. List of the KEGG pathways significantly associated with WGCNA’s modules detected using blood DEG.
MOESM1 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 1. Means (±SD) and significance for Body weight at 17 weeks for the effect of the diet, the line and their interaction.
MOESM6 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 6. List of the KEGG pathways significantly associated with WGCNA’s modules detected using hypothalamic DEG.
MOESM2 of Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Additional file 2. List of the genes uniquely expressed in each tissue.