0000000000909435
AUTHOR
Isabel Muñoz-fambuena
showing 2 related works from this author
Cognitive impairment associated with chronic lead exposure in adults
2018
Abstract Lead (Pb) exposure interferes with many biochemical events present in cells of the central nervous system (neurons and astrocytes) and it can produce a wide spectrum of alterations including cognitive impairment. The review summarizes the main cognitive alterations induced by chronic Pb exposure in adults/older individuals. We have focused on the current state of knowledge concerning the most vulnerable brain areas to Pb exposure that accompanied by the long-lasting neurological effects of Pb in cognitive functions. We tried to correlate the cognitive deficits induced by Pb exposure in animal models during adulthood with those reported in humans. The great interest in whether expos…
Neurotransmitters and Behavioral Alterations Induced by Nickel Exposure.
2020
Background:: Nickel ions (Ni2+) are a heavy metal with wide industrial uses. Environmental and occupational exposures to Ni are potential risk factors for brain dysfunction and behavioral and neurological symptoms in humans. Methods: We reviewed the current evidence about neurochemical and behavioral alterations associated with Ni exposure in laboratory animals and humans. Results: Ni2+ exposure can alter (both inhibition and stimulation) dopamine release and inhibit glutamate NMDA receptors. Few reports claim an effect of Ni2+ at the level of GBA and serotonin neurotransmission. At behavioral levels, exposure to Ni2+ in rodents alters motor activity, learning and memory as well as anxiety…