0000000000909733
AUTHOR
C Cortell
Comparative enhancer effects of Span20 with Tween20 and Azone on the in vitro percutaneous penetration of compounds with different lipophilicities.
Sorbitan monolaurate (Span20) was used in this study to analyze the influence of the polar functional group on the effects that non-ionic surfactants have on skin permeability. Its ethoxylate derivative polysorbate 20 (Tween20) and Azone, both with the same C12 alkyl chain as Span20, were used for comparative purposes. We evaluated the relative potency of the three molecules as enhancers in the permeability of a series of compounds with lipophilicities ranging from log Poct=-0.95 to log Poct=2.33. The influence of the enhancer concentration was also studied. For this purpose the epidermis of Wistar rat was pretreated with ethanolic solutions (1 and 5%, w/v) of each enhancer. Our results ind…
3PC-030 Physical, chemical and microbiological stability of sirolimus 0.4% in topical formulations
Background Facial angiofibromas in tuberous sclerosis are an aesthetic problem within the clinical context of the disease. There are currently few stability studies that allow selecting the best topical sirolimus therapy. Purpose To improve the formulation of sirolimus 0.4% for the treatment of facial angiofibromas in tuberous sclerosis and to determine the period of validity (physical, chemical and microbiological stability) of the proposed formulations. Material and methods Three formulations of sirolimus 0.4% were prepared (each in duplicate, A and B). Facilities and equipment: biological safety cabinet with individual protection equipment for the manipulator. Conditions: aluminum tubes,…