0000000000910371

AUTHOR

Lois Muiva-mutisya

showing 2 related works from this author

Prenylated Flavonoids from the Roots of Tephrosia rhodesica

2020

Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. peerReviewed

Plasmodium falciparumPharmaceutical Sciencemolecular structurehernekasvitCrystallography X-Ray01 natural sciencesPlant RootsArticleAnalytical ChemistryAntimalarialsflavonoiditPrenylationDrug DiscoveryBiological sciencesBiologynuclear magnetic resonance spectroscopyPharmacologyFlavonoidsPrenylationantimikrobiset yhdisteetOrganisk kemiChromatographybiologyStrain (chemistry)Molecular Structure010405 organic chemistryTephrosiaChemistrySpectrum AnalysisPharmacology. TherapycarbonOrganic ChemistryPlasmodium falciparumbiology.organism_classificationcircular dichroism spectroscopyluonnonaineetMass spectrometric0104 chemical sciences010404 medicinal & biomolecular chemistryChemistryComplementary and alternative medicineTephrosiaMolecular MedicineSpectrum analysismetabolism
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CCDC 1987379: Experimental Crystal Structure Determination

2020

Related Article: Yoseph Atilaw, Lois Muiva-Mutisya, Jonathan Bogaerts, Sandra Duffy, Arto Valkonen, Matthias Heydenreich, Vicky M. Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2020|J.Nat.Prod.|83|2390|doi:10.1021/acs.jnatprod.0c00245

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters5'7'-dihydroxy-57-dimethoxy-88'-bis(3-methylbut-2-en-1-yl)-22'-diphenyl-2'33'4-tetrahydro-2H4'H-[46'-bi-1-benzopyran]-4'-oneExperimental 3D Coordinates
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