6533b851fe1ef96bd12a9817
RESEARCH PRODUCT
Prenylated Flavonoids from the Roots of Tephrosia rhodesica
Jonathan BogaertsYoseph AtilawYoseph AtilawLois Muiva-mutisyaMáté ErdélyiMáté ErdélyiKari RissanenMatthias HeydenreichArto ValkonenAbiy YenesewSandra DuffyVicky M. Averysubject
Plasmodium falciparumPharmaceutical Sciencemolecular structurehernekasvitCrystallography X-Ray01 natural sciencesPlant RootsArticleAnalytical ChemistryAntimalarialsflavonoiditPrenylationDrug DiscoveryBiological sciencesBiologynuclear magnetic resonance spectroscopyPharmacologyFlavonoidsPrenylationantimikrobiset yhdisteetOrganisk kemiChromatographybiologyStrain (chemistry)Molecular Structure010405 organic chemistryTephrosiaChemistrySpectrum AnalysisPharmacology. TherapycarbonOrganic ChemistryPlasmodium falciparumbiology.organism_classificationcircular dichroism spectroscopyluonnonaineetMass spectrometric0104 chemical sciences010404 medicinal & biomolecular chemistryChemistryComplementary and alternative medicineTephrosiaMolecular MedicineSpectrum analysismetabolismdescription
Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |