0000000000916365
AUTHOR
Ting Liu
mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function
Cells respond to iron deficiency by activating iron-regulatory proteins to increase cellular iron uptake and availability. However, it is not clear how cells adapt to conditions when cellular iron uptake does not fully match iron demand. Here, we show that the mRNA-binding protein tristetraprolin (TTP) is induced by iron deficiency and degrades mRNAs of mitochondrial Fe/S-cluster-containing proteins, specifically Ndufs1 in complex I and Uqcrfs1 in complex III, to match the decrease in Fe/S-cluster availability. In the absence of TTP, Uqcrfs1 levels are not decreased in iron deficiency, resulting in nonfunctional complex III, electron leakage, and oxidative damage. Mice with deletion of Ttp …
Metamorphic P–T paths for the Archean Caozhuang supracrustal sequence, eastern Hebei Province, North China Craton: Implications for a sagduction regime
Abstract Archean supracrustal rocks of amphibolite-facies occur as enclaves within granitoids gneiss domes and belts between domes, representing collision or sagduction regimes. In order to distinguish between tectonic regimes using metamorphic patterns, systematic data on metamorphic evolution and zircon age dating are presented for the Caozhuang supracrustal sequence of eastern Hebei Province, China, which occurs as enclaves in gneisses. A garnet biotite gneiss records a P–T path involving pre-peak isobaric heating to peak conditions at 780–800 °C and 10–11 kbar (medium-P/T type), followed by decompression to 5–6 kbar. Two Mg/Al-rich schists from the same locality show low P/T conditions …