Correlation among pAKT, pERK1/2 and DNA fragmentation index in human cumulus cells to determine oocyte competence

The aim was to correlate specific biological aspects of cumulus cells isolated from individual cumulus-oocyte complexes (COCs) with the clinical outcome of the related embryos.

POTENTIAL IMPACT OF A NONAVALENT VACCINE ON HPV RELATED LOW-AND HIGH-GRADE CERVICAL INTRAEPITHELIAL LESIONS

Introduction: Demonstration of the role of persistent infection, with high-risk (HR) human papillomaviruses (HPV) as the causal agent of cervical cancer made the development of first and second generation prophylactic vaccines. Bivalent and quadrivalent HPV vaccines are at the moment available in Europe. In 2014 is licensing a nonavalent HPV vaccine against HPV types: 6/11/16/18/31/33/45/52/58. The aim of our study was to evaluate the potential impact on HPV infection and related low- and high-grade cervical lesions (LSIL, HSIL) of the candidate nonavalent HPV vaccine, compared to the impact of the quadrivalent, in a female population living in Sicily. Materials and Methods: HPV genotypes w…

Analysis of persistence of human papillomavirus infection in men evaluated by sampling multiple genital sites.

Although human papillomavirus (HPV) infection has been studied extensively in women, data on male infection are limited. The purpose of this study was to investigate persistence of HPV infection at multiple genital sites in men and to define potential associations with socio-behavioural characteristics.Penile, urethral and seminal specimens were tested by the INNO-LiPA HPV system (Innogenetics) and a PCR assay. Persistence was defined as the detection of same HPV type at ≥ 2 consecutive visits. The Kaplan-Meier method and the log-rank test were applied to estimate the likelihood of persistence.A total of 50 men (median age: 33 years) were followed for a median of 14.7 months. Altogether, 49…

The burnout phenomenon among student radiographers: a single centre experience

Burnout syndrome is a condition that may occur not only for staff in human service sectors/jobs, involving intensive interactions with others, but also people that are engaged in activities psychologically similar to work, such as students. Radiographers in training suffer double stress, first linked to the status of being a university student and secondly as early career workers who have relations with the public of the health system. Aim of our study was to investigate the prevalence and levels of burnout syndrome among radiographers in training in an University Hospital.In order to gain a better understanding of nature of the burnout syndrome a modified version of Maslach's questionnaire…

Indicazioni per uno Studio su Familiarità e fattori di rischio del Sarcoma di Kaposi classico

Obiettivi: Dalle analisi dei dati degli studi precedenti effettuati in Sicilia sono emerse diverse indicazioni, per cui è stata avviata un’indagine in Sicilia nel 2013 , grazie ad un finanziamento della LILT nazionale, intesa a: valutare la situazione immunologica ed ematochimica e la sieroprevalenza in persone a stretto contatto con i malati (parente di 1 grado o marito/moglie) o parenti affetti dalla stessa patologia; indagare alcuni fattori di rischio con un questionario;effettuare il follow-up dei malati ogni 6-12-18-24 mesi ; individuare un Centro di Riferimento in Sicilia per la diagnosi e cura di questo tumore raro. Materiali e Metodi: Sono stati arruolati 24 Casi (21M/3F) e 27 Contr…

GASTRIC CANCER (GC) ADJUVANT (A) CHEMOTHERAPY (CT): A LITERATURE BASED META-ANALYSIS (MA)

MISURARE LE DISUGUAGLIANZE SOCIO-ECONOMICHE NELLE MALATTIE CRONICHE IN RELAZIONE ALLO STILE DI VITA

In Europa, le principali malattie non trasmissibili (MNT), comprendono il diabete, le malattie cardiovascolari, il cancro, le malattie respiratorie croniche e i disturbi mentali, e rappresentano complessivamente circa l'86% delle morti e il 77% della spesa sanitaria. Delle sei regioni dell'OMS, la regione europea è quella più colpita dalle MNT (WHO, 2014). È stato dimostrato che almeno l'80% di tutte le malattie cardiache, ictus e diabete di tipo 2 e almeno un terzo dei casi di cancro sono evitabili (WHO, 2013). La strategia di sorveglianza globale di OMS sulle MNT si basa su una visione multidimensionale di determinanti della malattia in cui i fattori di rischio sono raggruppati lungo la t…

SEDENTARINESS AND EDUCATION CONTRIBUTE SIGNIFICANTLY TO SOCIOECONOMIC INEQUALITIES IN NON-COMMUNICABLE DISEASES

In Europe, the main non-communicable diseases (NCDs), including diabetes, cardiovascular diseases, cancer, chronic respiratory diseases and mental disorders, all together account for an estimated 86% of the deaths and 77% of the disease burden. Of the six WHO regions, Europe is the most affected by NCDs [1]. The detection and control of physiological and behavioral risk factors (BRFs) remain the essential preventive strategy to counteract not only the average population’s exposure to the main NCDs, but also socioeconomic inequalities, which are related to chronic diseases. The scope of this work is to investigate socioeconomic inequalities among the European elderly in NCDs and BRFs for NCD…

Whole-body diffusion weighted MR and FDG-PET/CT in Hodgkin lymphoma: predictive role before treatment and early assessment aftrer two courses of chemotheraphy

To evaluate whether whole-body MR has a predictive role before treatment and may asses the response after two courses of chemotherapy in comparison to FDG-PET/CT

Supplementary Material for: Italian Deprivation Index and Dental Caries in 12-Year-Old Children: A Multilevel Bayesian Analysis

Evidence from the literature has shown that people with a lower socioeconomic status enjoy less good health than people with a higher socioeconomic status. The Italian deprivation index (DI) was used with the aim to evaluate the association between the DMFT index and risk factors for dental caries, including city population and DI. The study included 4,305 12-year-old children living in 38 cities classified by demographic size as small, midsize and large. Zero-inflated negative binomial multilevel regression models were used to assess risk factors for DMFT and to address excess of zero DMFT and overdispersion through a Bayesian approach. The difference in the average level of DMFT among chi…