0000000000919482
AUTHOR
Iouri L. Soldatski
Distribution and density of CD1a+ and CD83+ dendritic cells in HPV-associated laryngeal papillomas.
Summary Background Respiratory papillomatosis associated with human papilloma virus (HPV) infection is the most common benign laryngeal neoplasm. The age of patients at disease onset, HPV type, number of surgeries are well known prognostic factors of the disease course. The correlation between dendritic cell (DC) density in tumor tissue and clinical prognosis was established. Aim The aim of our study was to estimate the density of DC in laryngeal papillomas associated with HPV types 6/11 infection and to evaluate the relationship between the number of DC and the disease severity. Materials and methods Our study included 40 randomly selected biopsy specimens from patients with HPV-positive l…
Children and partners of patients with recurrent respiratory papillomatosis have no evidence of the disease during long-term observation.
Summary Objective Recurrent respiratory papillomatosis (RRP) is the most common benign neoplasm affecting the larynx and upper respiratory tract. The aim of our study was to investigate whether children and partners of patients with RRP develop the same disease and to determine whether there is an impact of pregnancy on the course of RRP. Patients and methods Thirty-eight of 42 patients with RRP were accepted for a multicenter prospective study in Germany in 21.06.83–12.03.90. Mean follow-up duration was 15.3 ± 1.8 years. The data of partners of patients with RRP was collected during the period of observation and then updated via interviews in January 2006. Twenty-nine children and four gra…