0000000000925557

AUTHOR

Jelena Pahomova

showing 3 related works from this author

Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study

2018

Aims: The aim of the study was to evaluate the rationale of blood pepsinogen (PG) testing in population based screening settings.Methods: Participants from a cross-sectional population-based study of cardiovascular risk factors in Latvia were invited to participate in the current study. Pepsinogen I and II were measured in blood samples taken during the initial study and at follow-up; upper gastrointestinal endoscopy was performed. There were three groups of patients: with moderately decreased (PG I< 70 ng/ml and PG I/PG II ratio < 3), with strongly decreased (PG I< 30 ng/ml and PG I/PG II ratio < 2), and with normal PG level. Biopsy with H. pylori detection was performed (updat…

AdultMalemedicine.medical_specialtyPopulationGastroenterologyEndoscopy GastrointestinalHelicobacter Infections03 medical and health sciences0302 clinical medicinePepsinStomach NeoplasmsPepsinogen AInternal medicine0502 economics and businessBiopsyPepsinogen CGastric mucosamedicineHumansMass ScreeningeducationMass screeningAgededucation.field_of_studyHelicobacter pyloribiologymedicine.diagnostic_testbusiness.industryStomach05 social sciencesGastroenterologyCancerMiddle AgedHelicobacter pyloribiology.organism_classificationmedicine.diseasemedicine.anatomical_structureDysplasiaElder Nutritional Physiological PhenomenaGastritisbiology.proteinFemale050211 marketing030211 gastroenterology & hepatologyAtrophybusinessJournal of Gastrointestinal and Liver Diseases
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Prevalence of Helicobacter pylori infection and atrophic gastritis in Latvia.

2012

Helicobacter pylori infection and atrophic gastritis are related to an increased risk for gastric cancer. There is a decrease in global H. pylori prevalence. We analyzed the prevalence of H. pylori infection in Latvia by the plasma IgG test and the presence of atrophy by means of pepsinogen testing.This subanalysis was carried out on a randomly selected cross-sectional sample of a general population of adults to access cardiovascular risk factors. Plasma samples were screened for H. pylori IgG (cutoff value 24 U/ml), and pepsinogens (Pg) I and II. Pg cutoff values of PgI/PgII ≤ 3 and PgI ≤ 70 ng/ml were used to assess the prevalence of atrophy of any grade and PgI/PgII ≤ 2 and PgI ≤ 30 ng/m…

AdultGastritis AtrophicMalemedicine.medical_specialtyHelicobacter pylori infectionAdolescentCross-sectional studyAtrophic gastritisGastroenterologySeverity of Illness IndexHelicobacter InfectionsYoung AdultAtrophySex FactorsPredictive Value of TestsRisk FactorsStomach NeoplasmsInternal medicinePepsinogen AmedicinePepsinogen CPrevalenceHumansYoung adultAgedAged 80 and overChi-Square DistributionHepatologybiologyHelicobacter pyloribusiness.industryGastroenterologyAge FactorsCancerMiddle Agedbacterial infections and mycosesmedicine.diseaseAntibodies BacterialLatviaCross-Sectional Studiesbiology.proteinLinear ModelsFemaleGastritismedicine.symptomAntibodybusinessPrecancerous ConditionsBiomarkersEuropean journal of gastroenterologyhepatology
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Prevalence estimation of celiac disease in the general adult population of Latvia using serology and HLA genotyping

2015

Background: Prevalence estimates for celiac disease (CD) depend on the method used. The role of deamidated gliadin peptide (DGP) and genetic testing in epidemiological studies and diagnostic settings of celiac disease (CD) has still to be established. Objectives: The objective of this article is to assess the prevalence of CD in Latvia by combining serological tests with DQ2.5/ DQ8 testing. Methods: A total of 1444 adults from a randomly selected cross-sectional general population sample were tested by ELISA for tTG IgA, DGP IgA and IgG antibodies (QUANTA Lite, Inova Diagnostics Inc). Samples with tTG IgA 20U were tested for EMA IgA by indirect immunofluorescence assay, and all specimens wi…

medicine.medical_specialty:MEDICINE [Research Subject Categories]Tissue transglutaminasePopulationSerologyChemiluminescent assaysEpidemiologyGenotypePrevalenceCeliac diseaseMedicineDQ2.5/8 genotypeeducationGenotypingGenetic testingeducation.field_of_studyDeamidated gliadin peptidemedicine.diagnostic_testbiologybusiness.industryTissue transglutaminaseGastroenterologynutritional and metabolic diseasesOriginal ArticlesOncologyImmunologybiology.proteinAntibodybusinessUnited European Gastroenterology Journal
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