0000000000928442
AUTHOR
Binquet Christine
Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients.
Background Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Phospholipids are now well-recognised players in tumour progression. Their metabolic tissue alterations can be associated with plasmatic modifications. The aim of this study was to evaluate the potential of the plasma phospholipid profile as a risk and prognostic biomarker in HCC. Methods Ninety cirrhotic patients with (cases) or without HCC (controls) were studied after matching for inclusion centre, age, gender, virus infection, cirrhosis duration and Child-Pugh grade. High-performance liquid chromatography coupled with tandem-mass spectrometry was used to quantify the main species of seven categories of …
182 Does emergency physician prehospital management improve outcome of severe blunt trauma?
Severe blunt traumas are a leading cause of premature death and handicap. The benefit for the patient of pre-hospital management by emergency physicians remains under debate because of possible delayed hospital admission. This study aimed at comparing the impact of basic life support (BLS) performed by fire brigades with advanced life support (ALS) performed by SMUR (Service Mobile d9Urgences et de Reanimation) physicians, on 30-day mortality. The FIRST study (French Intensive Care Recorded Severe Trauma) is a French observational multicentric study designed in order to describe the modalities of severe blunt trauma management. The study population was composed of trauma patients over 18 ye…