La produzione libertina di François-Antoine Chevrier

COVID-19 temporally related multisystem inflammatory syndrome (MIS-C): an early window of opportunity is a good treatment strategy? The experience of the paediatric covid center in Palermo

Introduction: Multi-system inflammatory syndrome in children (MISC) shows a presentation mimicking Kawasaki Disease (KD), Toxic Shock Syndrome (TSS), Macrophage Activation Syndrome (MAS). Furthermore, many children show respiratory or abdominal symptoms. Objectives: Intravenous immunoglobulin (IVIG) is recommended as first line treatment as in KD, followed by aspirin, steroids and, in IVIGresistant patients, IL-1 or IL-6 blocking agents. Methods: We describe a cohort of 16 Sicilian children (6M;10F; age:1.4-14 years), with MIS-C, with clinical features compatible with classical or incomplete KD, in some cases with MAS and/or TSS. Demographic, clinical, laboratory, echocardiographic and imag…

INSIDIE DIAGNOSTICHE DELLA TROMBOSI VENOSA CEREBRALE: STORIA DI UN CASO CLINICO

Introduzione: la trombosi venosa cerebrale (TVC) è una condizione rara, le manifestazioni sono spesso elusive, i primi reperti radiologici non d‘immediato riscontro e quindi trascurabili. La prognosi neurologica è variabile ma nell'80% dei casi è favorevole. Incidenza: 7 bambini milione/anno. Clinica: cefalea improvvisa, convulsioni, coma, alterazioni oculari i più frequenti. I fattori di rischio, in accordo con la triade di Virchow: trombofilia congenita o acquisita, danno endoteliale (es: flogosi, infezioni) e stasi del flusso sanguigno (es: policitemia). Diagnosi: anamnesi, esame obiettivo, Rm cerebrale, in alternativa eseguire la TC encefalo, se queste negative può essere utile un'angio…

Effects of amsacrine (m-AMSA), a new aminoacridine antitumor drug, on the rabbit heart.

There is emerging clinical evidence that amsacrine (m-AMSA) administration may be associated with cardiotoxic effects such as severe, even fatal, ventricular arrhythmias and impairment of the inotropic performance of the heart. Information on the cardiac effects of m-AMSA in animals is scanty. Studies on mice, dogs, and monkeys have not evidenced the cardiotoxicity of the compound. The data presented in this paper show that m-AMSA causes acute ECG alterations in normal rabbits and a dose-related negative inotropic effect on the isolated rabbit heart, suggesting that this species may be a useful model for the study of the cardiac actions of this antiblastic.