0000000000932048
AUTHOR
Xiaoyan Zhu
showing 2 related works from this author
Targeting aurora kinase B alleviates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury.
2019
Peripheral nerve injury elicits spinal microgliosis, contributing to neuropathic pain. The aurora kinases A (AURKA), B (AURKB), and C (AURKC) are potential therapeutic targets in proliferating cells. However, their role has not been clarified in microglia. The aim of this study was to examine the regulation of aurora kinases and their roles and druggability in spinal microgliosis and neuropathic pain. Sprague-Dawley rats received chronic constriction injury (CCI). Gene expression of aurora kinases A-C was evaluated by quantitative RT-PCR and western blot, respectively, in spinal cords at 1, 3, 7, and 14 days after CCI. AURKB gene and protein expression was up-regulated concomitantly with th…
Neural Multimodal Belief Tracker with Adaptive Attention for Dialogue Systems
2019
Multimodal dialogue systems are attracting increasing attention with a more natural and informative way for human-computer interaction. As one of its core components, the belief tracker estimates the user's goal at each step of the dialogue and provides a direct way to validate the ability of dialogue understanding. However, existing studies on belief trackers are largely limited to textual modality, which cannot be easily extended to capture the rich semantics in multimodal systems such as those with product images. For example, in fashion domain, the visual appearance of clothes play a crucial role in understanding the user's intention. In this case, the existing belief trackers may fail …