Identification of genotoxic and endocrine disruption activities of 4,4’-dihydroxydiphenyl-methane (BPF) and its metabolites using human cell lines

Etude du métabolisme in vitro du bisphénol F

Impact d’une exposition périnatale à de faibles doses de Bisphénol A (BPA) sur le métabolisme chez la souris CD1

National audience

Disposition and metabolic profiling of bisphénol F in pregnant and non pregnant rat

Evidence for metabolic disruption in CD1 mice following exposure to low doses of bisphenol A (BPA)

International audience

Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line

International audience; Human can be exposed to bis(hydroxyphenyl)methane (bisphenol F or BPF) and its derivatives as environment and food's contaminants. This study was investigated to identify and to compare toxic potency of BPF, BFDGE, and two of BPF metabolites using in vitro methods. BPF did not induce any genic mutation in bacteria when the Ames test was performed according to the OECD guideline. In contrast, using Human cell lines and Comet assay, we demonstrated that BPF and Bisphenol F Diglycidyl Ether (BFDGE) were effective on HepG2 cell DNA fragmentation at non-cytotoxic concentrations. DHB was also positive but at higher concentrations, near its limit of solubility. Neither BPF,…

A CASCADE of effects of bisphenol A

International audience

Metabolic disruption in male CD-1 mice perinatally exposed to low doses of Bisphenol A (BPA)

International audience