0000000000934514
AUTHOR
Shin-ichiro Nishimura
Persistence of the Z=28 shell gap in A=75 isobars: Identification of a possible (1/2−) μs isomer in Co75 and β decay to Ni75
Background: The evolution of shell structure around doubly-magic exotic nuclei is of great interest in nuclear physics and astrophysics. In the `south-west' region of $^{78}$Ni, the development of deformation might trigger a major shift in our understanding of explosive nucleosynthesis. To this end, new spectroscopic information on key close-lying nuclei is very valuable. Purpose: We intend to measure the isomeric and $\beta$ decay of $^{75}$Co, with one proton- and two neutron-holes relative to $^{78}$Ni, to access new nuclear structure information in $^{75}$Co and its $\beta$-decay daughters $^{75}$Ni and $^{74}$Ni. Methods: The nucleus $^{75}$Co is produced in relativistic in-flight fiss…
Impact of a Three Amino Acid Deletion in the CH2 Domain of Murine IgG1 on Fc-Associated Effector Functions
Abstract Four murine IgG subclasses display markedly different Fc-associated effector functions because of their differential binding to three activating IgG Fc receptors (FcγRI, FcγRIII, and FcγRIV) and C1q. Previous analysis of IgG subclass switch variants of 34-3C anti-RBC monoclonal autoantibodies revealed that the IgG1 subclass, which binds only to FcγRIII and fails to activate complement, displayed the poorest pathogenic potential. This could be related to the presence of a three amino acid deletion at positions 233–235 in the CH2 domain uniquely found in this subclass. To address this question, IgG1 insertion and IgG2b deletion mutants at positions 233–235 of 34-3C anti-RBC Abs were …
Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions.
Abstract Replacement of aspartic acid by alanine at position 265 (D265A) in mouse IgG1 results in a complete loss of interaction between this isotype and low-affinity IgG Fc receptors (FcγRIIB and FcγRIII). However, it has not yet been defined whether the D265A substitution could exhibit similar effects on the interaction with two other FcγR (FcγRI and FcγRIV) and on the activation of complement. To address this question, 34-3C anti-RBC IgG2a and IgG2b switch variants bearing the D265A mutation were generated, and their effector functions and in vivo pathogenicity were compared with those of the respective wild-type Abs. The introduction of the D265A mutation almost completely abolished the…