0000000000934804
AUTHOR
Marcos Bruna Esteban
Preoperative nutritional deficiencies: epidemiology and prevalence of nutritional deficiencies among morbidly obese patients, specifying which ones should be supplemented
Abstract Micronutrient deficiency is common in obese patients admitted for bariatric surgery, especially, a considerable prevalence of low levels of vitamin D, folic acid, vitamin B1, vitamin B12, vitamin A, vitamin E, zinc, iron, and selenium has been demonstrated. Patients who are candidates for bariatric surgery usually present various factors that cause the appearance of these deficiencies (inappropriate eating behavior, alcohol consumption, chronic subclinical infiammation, several diseases, and medications that can impact the blood levels of micronutrients). This higher prevalence of micronutrient deficiencies in obese people could also promote postoperative complications and postoper…
Genetic screening for MC4R gene identifies three novel mutations associated with severe familiar obesity in a cohort of Spanish individuals
Abstract MC4R gene is a hypothalamic satiety control mediator in which mutations cause a monogenic form of obesity. The aim of this study was to perform a genetic screening to identify variations in the entire region of MC4R gene. A total of 236 unrelated and severely obese patients (BMI ≥ 40 kg/m2) with Spanish ancestry and severe overweight familiar history have been enrolled into the study. Seven MC4R gene variants were identified in the heterozygous state in 21 patients. Coding variants p.Thr101Ile and p.Ala259Asp are new and variants p.Ser30Phe, p.Val103Ile and p.Ile251Leu were previously described. Two variants have been also observed in the promoter region of the MC4R gene; the c.-24…
Modelo predictivo de mortalidad a largo plazo en el trasplante hepático del adulto
El trasplante hepático es el tratamiento de elección de muchas hepatopatías terminales y un procedimiento que ha ido evolucionando desde sus inicios, mejorando sus resultados con el paso del tiempo. A pesar de que nuestro país es uno de los que presentan las tasas de donación más altas del mundo, debido al incremento en el número de indicaciones para la realización de un trasplante hepático, porcentaje de pacientes que fallecen en lista de espera se cifra en torno al 5 %. Por ello se continúa investigando y buscando modelos predictivos y de asignación de injertos a fin de mejorar la eficiencia global del procedimiento. En nuestro trabajo planteamos como objetivo el desarrollo de un modelo p…