0000000000937423

AUTHOR

John C. Rothwell

showing 5 related works from this author

In vivo definition of parieto-motor connections involved in planning of grasping movements

2010

We combined bifocal transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) tractography to investigate in humans the contribution of connections originating from different parietal areas in planning of different reaching to grasp movements. TMS experiments revealed that in the left hemisphere functional connectivity between the primary motor cortex (M1) and a portion of the angular gyrus (AG) close to the caudal intraparietal sulcus was activated during early preparation of reaching and grasping movements only when the movement was made with a whole hand grasp (WHG) towards objects in contralateral space. In contrast, a different pathway, linking M1 with a part of the su…

Malegenetic structuresCognitive Neurosciencemedicine.medical_treatmentIntraparietal sulcusMotor Activitybehavioral disciplines and activitiesFunctional LateralityLateralization of brain functionNOSuperior longitudinal fasciculusAngular gyrusYoung AdultSupramarginal gyrusParietal LobeNeural PathwaysmedicineHumansYoung Adult; Diffusion Tensor Imaging; Humans; Hand; Motor Skills; Parietal Lobe; Frontal Lobe; Motor Cortex; Evoked Potentials Motor; Motor Activity; Neural Pathways; Psychomotor Performance; Transcranial Magnetic Stimulation; Female; Functional Laterality; MaleEvoked PotentialsConnectivitySettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamusculoskeletal neural and ocular physiologySuperior longitudinal fasciculusMotor CortexEvoked Potentials MotorHandTranscranial Magnetic StimulationFrontal LobeTranscranial magnetic stimulationTMS Connectivity Movement planning Superior longitudinal fasciculusTractography Transcranial magnetic stimulationDiffusion Tensor Imagingmedicine.anatomical_structureConnectivity; Movement planning; Superior longitudinal fasciculus; TMS; Tractography; Transcranial magnetic stimulation;Motornervous systemNeurologyMotor SkillsMovement planningTMSFemaleSettore MED/26 - NeurologiaPrimary motor cortexPsychologyTractographyNeurosciencePsychomotor Performancepsychological phenomena and processesTractographyNeuroImage
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TMS activation of interhemispheric pathways between the posterior parietal cortex and the contralateral motor cortex

2009

Using a twin coil transcranial magnetic stimulation (tc-TMS) approach we have previously demonstrated that facilitation may be detected in the primary motor cortex (M1) following stimulation over the ipsilateral caudal intraparietal sulcus (cIPS). Here we tested the interhemispheric interactions between the IPS and the contralateral motor cortex (M1). We found that conditioning the right cIPS facilitated contralateral M1 when the conditioning stimulus had an intensity of 90% resting motor threshold (RMT) but not at 70% or 110% RMT. Facilitation was maximal when the interstimulus interval (ISI) between cIPS and M1 was 6 or 12 ms. These facilitatory effects were mediated by interactions with …

PhysiologyInterstimulus intervalmedicine.medical_treatmentParietal lobePosterior parietal cortexStimulationIntraparietal sulcusTranscranial magnetic stimulationmedicine.anatomical_structuremedicinePrimary motor cortexPsychologyNeuroscienceMotor cortexThe Journal of Physiology
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TMS-evoked long-lasting artefacts: A new adaptive algorithm for EEG signal correction

2017

Abstract Objective During EEG the discharge of TMS generates a long-lasting decay artefact (DA) that makes the analysis of TMS-evoked potentials (TEPs) difficult. Our aim was twofold: (1) to describe how the DA affects the recorded EEG and (2) to develop a new adaptive detrend algorithm (ADA) able to correct the DA. Methods We performed two experiments testing 50 healthy volunteers. In experiment 1, we tested the efficacy of ADA by comparing it with two commonly-used independent component analysis (ICA) algorithms. In experiment 2, we further investigated the efficiency of ADA and the impact of the DA evoked from TMS over frontal, motor and parietal areas. Results Our results demonstrated t…

MaleTime Factorsmedicine.medical_treatmentElectroencephalographySignal0302 clinical medicineSignal correctionDetrendEEGAdaptive algorithmmedicine.diagnostic_test05 social sciencesElectroencephalographyTranscranial Magnetic StimulationSensory SystemsAlgorithmNeurologyArtefact; Detrend; EEG; ICA; TMS; Sensory Systems; Neurology; Neurology (clinical); Physiology (medical)ArtifactFemalePrimary motor cortexArtifactsPsychologyAlgorithmsHumanAdultTime Factor050105 experimental psychologyNOYoung Adult03 medical and health sciencesPhysiology (medical)medicineHumansMiddle frontal gyrus0501 psychology and cognitive sciencesICAArtefactSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabusiness.industryPattern recognitionIndependent component analysisTranscranial magnetic stimulationTMSNeurology (clinical)Artificial intelligenceSensory SystembusinessNeuroscience030217 neurology & neurosurgeryClinical Neurophysiology
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Hyperexcitability of parietal-motor functional connections in the intact left-hemisphere of patients with neglect

2008

Hemispatial neglect is common after unilateral brain damage, particularly to perisylvian structures in the right-hemisphere (RH). In this disabling syndrome, behaviour and awareness are biased away from the contralesional side of space towards the ipsilesional side. Theoretical accounts of this in terms of hemispheric rivalry have speculated that the intact left-hemisphere (LH) may become hyper-excitable after a RH lesion, due to release of inhibition from the damaged hemisphere. We tested this directly using a novel twin-coil transcranial magnetic stimulation (TMS) approach to measure excitability within the intact LH of neglect patients. This involved applying a conditioning TMS pulse ove…

Malegenetic structuresmedicine.medical_treatmentHumans; Stroke; Aged; Parietal Lobe; Motor Cortex; Evoked Potentials Motor; Adult; Neural Pathways; Middle Aged; Psychomotor Performance; Transcranial Magnetic Stimulation; Female; Functional Laterality; Male; Perceptual DisordersParietal cortexFunctional LateralityParietal LobeNeural PathwaysrTMSNeglect syndromeEvoked Potentialsmedia_commonConnectivityneglectParietal lobeMotor CortexCortical excitabilityMiddle AgedTranscranial Magnetic StimulationStrokemedicine.anatomical_structureMotorSettore MED/26 - NeurologiaFemalemedicine.symptomPerceptual DisorderPsychologyMotor cortexHumanAdultmedia_common.quotation_subjectPosterior parietal cortexArticleLateralization of brain functionrehabilitationNeglectNOPerceptual DisordersNeural PathwaymedicineHumansAgedHemispatial neglectEvoked Potentials MotorTranscranial magnetic stimulationneglect syndrome; transcranial magnetic stimulation; connectivity; rTMS; parietal cortex; cortical excitabilityUnilateral neglectTMSNeurology (clinical)NeurosciencePsychomotor Performance
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Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials

2014

The neuromodulatory effects of repetitive transcranial magnetic stimulation (rTMS) have been mostly investigated by peripheral motor-evoked potentials (MEPs). New TMS-compatible EEG systems allow a direct investigation of the stimulation effects through the analysis of TMS-evoked potentials (TEPs).We investigated the effects of 1-Hz rTMS over the primary motor cortex (M1) of 15 healthy volunteers on TEP evoked by single pulse TMS over the same area. A second experiment in which rTMS was delivered over the primary visual cortex (V1) of 15 healthy volunteers was conducted to examine the spatial specificity of the effects. Single-pulse TMS evoked four main components: P30, N45, P60 and N100. M…

AdultMaleCognitive Neurosciencemedicine.medical_treatmentTMS; EEG; Inhibition; TEPs; N100; GABAbStimulationElectroencephalographyInhibitory postsynaptic potentialbehavioral disciplines and activitiesTMS; EEG; inhibition; GABAb; N100Young AdultmedicineHumansEEGN100Evoked PotentialsInhibitionVisual CortexN100Settore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamedicine.diagnostic_testTEPsmusculoskeletal neural and ocular physiologyMotor CortexElectroencephalographyNeural InhibitionTranscranial Magnetic StimulationTranscranial magnetic stimulationTEPVisual cortexmedicine.anatomical_structurenervous systemNeurologyTMSGABAbFemaleEvoked PotentialPrimary motor cortexPsychologyNeurosciencepsychological phenomena and processesHumanMotor cortexNeuroImage
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