0000000000939221

AUTHOR

Roberta Riccioni

showing 4 related works from this author

Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise

2010

J Appl Physiol. 2010 Jul;109(1):60-7. Epub 2010 May 6. Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise. Bonsignore MR, Morici G, Riccioni R, Huertas A, Petrucci E, Veca M, Mariani G, Bonanno A, Chimenti L, Gioia M, Palange P, Testa U. SourceBiomedical Department, Internal and Specialistic Medicine (DIBIMIS), Section of Pneumology, University of Palermo, Via Trabucco, 180, 90146 Palermo, Italy. marisa@ibim.cnr.it Abstract The effects of endurance or maximal exercise on mobilization of bone marrow-derived hemopoietic and angiogenetic progenitors in healthy subjects are poorly defined. In 10 healthy amateur runners, we collect…

AdultMalemedicine.medical_specialtyPhysiologyNeovascularization PhysiologicAntigens CD34Physical exerciseHematopoietic Cell Growth FactorsSettore BIO/09 - FisiologiaRunningangiopoietin; marathon; circulating progenitors; growth factorsAntigens CDEndurance trainingPhysiology (medical)Internal medicinegrowth factorsmedicineHumansAC133 AntigenProgenitor cellGlycoproteinsErythroid Precursor CellsbiologyAthletesbusiness.industryangiopoietinHealthy subjectsEndothelial Cellscirculating progenitorMiddle AgedCadherinsHematopoietic Stem Cellsbiology.organism_classificationHaematopoiesisEndocrinologyAthletesPhysical EnduranceCytokinesAngiogenesis Inducing Agentsadult; angiogenesis inducing agents; angiopoietin; antigens; athletes; blood; cadherins; cd; cd34; circulating progenitors; cytokines; endothelial cells; erythroid precursor cells; glycoproteins; granulocytes; growth factors; hematopoietic cell growth factors; hematopoietic stem cells; humans; male; marathon; middle aged; neovascularization; peptides; physical endurance; physiologic; physiology; runningAC133 antigenMaximal exercisemarathonPeptidesbusinessGranulocytesJournal of Applied Physiology
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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

2009

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…

aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismRespiratory physiologyneurobiology
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Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis

1999

Abstract The possible involvement of Fas and Fas ligand (FasL) in the regulation of erythropoiesis was evaluated. Immunohistochemistry of normal bone marrow specimens revealed that several immature erythroblasts undergo apoptosis in vivo. Analysis of bone marrow erythroblasts and purified progenitors undergoing unilineage erythroid differentiation showed that Fas is rapidly upregulated in early erythroblasts and expressed at high levels through terminal maturation. However, Fas crosslinking was effective only in less mature erythroblasts, particularly at basophilic level, where it induced apoptosis antagonized by high levels of erythropoietin (Epo). In contrast, FasL was selectively induced…

medicine.medical_specialtyPopulationImmunologyBiologyBiochemistryFas ligandReticulocyteSettore MED/04 - PATOLOGIA GENERALEInternal medicinehemic and lymphatic diseasesmedicineCytotoxic T celleducationeducation.field_of_studyhemic and immune systemsCell BiologyHematologyCell biologyHaematopoiesismedicine.anatomical_structureEndocrinologyErythropoietinApoptosisErythropoiesismedicine.drugcirculatory and respiratory physiology
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New data from the Italian National Register of Congenital Coagulopathies, 2016 Annual Survey

2018

BACKGROUND: In Italy, the National Register of Congenital Coagulopathies (NRCC) collects epidemiological and therapeutic data from patients affected by haemophilia A (HA), haemophilia B (HB), von Willebrand’s disease (vWD) and other rare coagulation disorders. Here we present data from the 2016 annual survey. MATERIALS AND METHODS: Data are provided by the Italian Haemophilia Centres, on a voluntary basis. Information flows from every Centre to a web-based platform of the Italian Association of Haemophilia Centres, shared with the Italian National Institute of Health, in accordance with current privacy laws. Patients are classified by diagnosis, disease severity, age, gender and treatment-r…

AdultMaleCanadaAdolescentAdolescent Adult Aged Blood Coagulation Factors Canada Child Coagulation Protein Disorders Factor IX Factor VIII Female France HIV Infections Hemophilia A Hemophilia B Hepatitis CHumans Infant Infant Newborn Italy Male Middle Aged Prevalence Registries Surveys and Questionnaires United Kingdom von Willebrand DiseasesHIV InfectionsCoagulation Protein DisordersHemophilia AHemophilia BFactor IXhemic and lymphatic diseasesSurveys and QuestionnairesPrevalenceHumansRegistriesChildAgedFactor VIIIInfant NewbornInfantMiddle AgedHepatitis CBlood Coagulation FactorsUnited Kingdomvon Willebrand DiseasesItalyChild PreschoolFemaleOriginal ArticleFrance
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