6533b82dfe1ef96bd1290b85
RESEARCH PRODUCT
Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.
Ugo TestaPaolo PalangeMaria R. BonsignoreMaria R. BonsignoreDaniela SaviEleonora PetrucciAlice HuertasRoberta RiccioniPietro SerraViviana Ritisubject
aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismdescription
Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C, HGF, Ang-2, TNF-alpha, IL-6 and MCP-1 levels. Furthermore, among patients with similar pulmonary impairment, those who displayed low-BMI had a more markedly reduced number of CD34(+) cells and late endothelial progenitors. We show that the reduction in hematopoietic and endothelial progenitor cells correlates with COPD severity. Our findings also indicate that, in severe low-BMI COPD patients, bone marrow function seems to be further impaired and may lead to reduced reparative capacity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-04-16 | Respiratory physiologyneurobiology |